摘要
目的探讨25(OH)D3水平对2型糖尿病抑郁症病情的影响,为临床治疗提供新思路。方法选择在该院住院治疗的2型糖尿病抑郁症患者,分为A、B二组,A组给予口服阿法骨化醇0.5μg/d,疗程4周。B组未给予口服阿法骨化醇。二组患者在住院当天和4周后分2次采集空腹外周静脉血5ml。血清中25(OH)D3水平测定采用化学发光法。认定70~80 nmol/L为正常水平。结果二组患者25(OH)D3水平、空腹及餐后血糖、抑郁量表评分等在补充阿法骨化醇前差异无统计学意义(P>0.05)。补充阿法骨化醇后,A组各项指标明显低于B组,随着25(OH)D3水平的升高A组患者抑郁评分明显降低,抑郁症状减轻,血清25(OH)D3水平与抑郁量表评分呈负相关(P<0.01),说明补充阿法骨化醇能改善抑郁症状,改善糖尿病血糖水平,差异有统计学意义(P<0.05)。结论维生素D可以改善2型糖尿病抑郁症患者的抑郁状态,减轻症状,是一种有效的治疗方法,可提高糖尿病抑郁症患者的生活质量。对2型糖尿病抑郁症患者进行血清25(OH)D3水平监测,并及时补充阿法骨化醇,为临床治疗提供了新思路。
Objective To analyze the influence of the 25（OH）D3-level on the depression in T2 DM patients and to develop new ideas for the clinic.Methods T2 DM patients with depression treated in author＇s hospital were observed and divided into two groups randomly,i.e.group A and group B.The patients in group A were treated with oral Alfacalcidol 0.5ug/d for 4 weeks;while the group B was not.About 5 ml fasting peripheral venous blood were collected twice from each patient in the two groups,the first time was done when the patients came to the hospital,and the second time was after 4-week treatment with oral Alfacalcidol.Chemiluminescence method was adopted to test 25（OH）D3-Level.The standard level is between70 and 80 nmol/L.Results There was no statistical significance among 25（OH）D3-Levels,the index of fasting and postprandial blood sugar,and scores of the self-rating depression scale（SDS）in the two groups before the treatment with oral Alfacalcidol（P〉0.05）.After the treatment,all indexes in group A were obviously lower than those in group B.Moreover,with the increase of 25（OH）D3-Level,the scores of SDS decreased obviously and the depression lightened that indicates 25（OH）D3-Level and the scores of SDS were correlated negatively（P〈0.01）.This showed that Alfacalcidol improved the depressive situation and the results of blood sugar test;the difference had statistical significance（P〈0.05）.Conclusion VD can improve the depressive situation of T2 DM patients and their live qualities effectively.The 25（OH）D3-Level of T2 DM patients with depression should be supervised and Alfacalcidol should be supplemented in time.This treatment can be taken into consideration in the clinic.
出处
《中国煤炭工业医学杂志》
2017年第2期183-185,共3页
Chinese Journal of Coal Industry Medicine
基金
河北省卫生厅计划项目(编号:20150536)
