摘要
目的探讨血清N-末端脑钠肽前体(NT-proBNP)用于急性冠脉综合征(ACS)的临床诊断价值。方法分别收集三组入院冠心病患者血清,包括28例稳定型心绞痛、33例不稳定型心绞痛、31例急性心肌梗死,以98例健康体检血清作为对照,检测各组血清的NT-proBNP和肌钙蛋白I(cTnI)水平。结果血清NT-proBNP浓度随患者罹患急性冠脉综合征的严重程度递增,差异具有统计学意义(P<0.05);以ROC曲线对NT-proBNP鉴别ACS的效能进行分析,其线下面积为0.79;对三组患者血清的NT-proBNP与cTnI的水平进行了相关性分析,NT-proBNP与cTnI在检测ACS中成线性相关(r=0.524,P<0.001)。结论 NT-proBNP是一种用于心衰诊断的较好的血清学标志物,可在鉴别患者急性冠脉综合征严重程度方面发挥良好的临床应用价值。
Objective To explore the clinical value of serum N-terminal pro B-type natriuretie peptide（NT-proBNP）in the diagnosis of acute coronary syndrome（ACS）.Methods We collected serum samples from patients with coronary heart disease included stable angina pectoris group（28 cases）,unstable angina pectoris group（33 cases）and acute myocardial infarction group（31 cases）;98 healthy people were used as control.The serum NT-proBNP,cardiac troponin I（cTnI）levels were detected in all subjects.ResultsThe concentration of NT-proBNP increased with the severity increased of the acute coronary syndrome,the difference was statistically significant（P〈0.05）;the efficacy of ROC curve area of NT-proBNP differential coronary heart disease was 0.79.By correlative analysis,NT-proBNP and cTnI in coronary artery disease showed a linear correlation（r=0.524,P〈0.001）.Conclusion NT-proBNP is a excellent serological diagnosis markers of heart failure,has high clinical value in the differential diagnosis of cute coronary syndrome severity.
出处
《中国煤炭工业医学杂志》
2017年第2期136-139,共4页
Chinese Journal of Coal Industry Medicine
基金
河北省卫生厅重点科技研究计划(编号:20150080)
关键词
N-末端脑钠肽前体
急性冠脉综合征
肌钙蛋白I
N-terminal pro B-type natriuretie peptide
Cute coronary syndrome
Cardiac troponin I
