摘要
基质金属蛋白酶（matrix metalloproteinases，MMPs）是一组降解细胞外基质的内源性蛋白酶系，其与基质金属蛋白酶组织抑制剂（tissue inhibitor of metallopmteinases，TIMPs）组成MMPs／TIMPs系统，降解和重塑细胞外基质。MMPs／TIMPs系统表达水平的失衡与眼病的发生发展密切关联，尤其是在各类眼表疾病中。目前认为结膜成纤维细胞中MMP-1、MMP-3及MMP-9过度表达是引起MMPs与TIMPs之间失去平衡的关键因素。MMPs与TIMPs之间失去平衡，使胶原纤维融解，弹力纤维变性减少，导致球结膜基质和Tenon囊的过度降解，引起眼表泪液异常的病理循环。眼表泪液的异常破坏了眼表环境的稳定性，参与多个眼表疾病如干眼、结膜松弛症、翼状胬肉、角膜炎等的病理变化。
Matrix metalloproteinases （MMPs） are a group of endogenous protease which degrades extracellular matrix system. Their inhibitors, tissue inhibitor of metalloproteinases （TIMPs） and MMPs systems, degrade and restore the extracellular matrix （ECM）. Expression level imbalance of MMPs and TIMPs system are closely related to the occurrence of ocular diseases, especially ocular surface diseases. It is believed that the excessive expression of MMPs, including MMP-1, MMP-3 and MMP-9 in fibroblasts in conjunctival stroma are key factors to cause imbalance between MMPs and TIMPs. Imbalance between MMPs and TIMPs leads to the melt of collagen fiber, elastic fiber degeneration, excessive degradation of conjuncti- val matrix and Tenon capsule, causing abnormal ocular surface tears. Ocular surface tear abnormality de- stroys the stability of the ocular surface environment, involved in many ocular surface diseases such as dry eye, eonjunctival relaxation, pterygium, keratitis, and many other pathological changes of ocular surface diseases.
作者
黄丽
项敏泓
张兴儒
HUANG Li XIANG Min-hong ZHANG Xing-ru.(Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, Chin)
出处
《国际眼科纵览》
2017年第1期32-37,共6页
International Review of Ophthalmology
基金
上海市普陀区自主创新科研基金（2013PTKW009）
关键词
基质金属蛋白酶
基质金属蛋白酶组织抑制剂
眼表疾病
matrix metalloproteinases
tissue inhibitor of metalloproteinases
ocular surface disease
