摘要
目的:观察青金栀汤治疗小儿急性毛细支气管炎患儿的临床疗效,并观察其对肺功能及炎症因子水平的影响。方法:88例小儿急性毛细支气管炎患儿随机平均分为对照组合观察组。对照组给予西医常规治疗;观察组在对照组治疗基础上给予青金栀汤。比较两组患儿治疗前后肺功能指标,包括达峰容积比、达峰时间比、潮气量及吸呼比;治疗前后两组患儿炎症因子水平,包括白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及超敏C反应蛋白(high-sensitivity c-reactive protein,hs-CRP)水平;比较两组治疗后临床疗效,治疗期间不良反应。结果:对照组有效率为81.82%,观察组有效率为97.73%,两组比较,差异有统计学意义(P<0.05);与治疗前比较,治疗后两组患儿肺功能指标达峰容积比、达峰时间比、潮气量及吸呼比均明显改善(P<0.05),且观察组改善程度较对照组显著(P<0.05);两组患儿炎症因子IL-6、TNF-α及hs-CRP水平较治疗前均显著降低(P<0.01),且观察组下降幅度较对照组显著(P<0.01);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:青金栀汤治疗小儿急性毛细支气管炎疗效显著,能有效改善患儿肺功能,降低患儿血清炎症因子水平,疗效确切,且安全可靠。
Objective ： To study the effects of Qing Jin Zhi Decoction on pulmonary function and inflammatory factor level of children ＇s acute bronchiolitis （AB ,for short）. Methods：88 cases of children with acute bronchiolitis were selected and randomly divided into two groups. The control group adopted conventional treatment with western medicine. On the basis of the therapy of the control group, that of the observation group was combined with Qing Jin Zhi Decoction. Children＇s pulmonary function indicators before and after the treatment of the two groups were recorded and compared, including volume ratio of peak （ VPEF/VE ）, time of peak ratio, tidal volume （TV） and respiratory ratio （TI/TE） ;and inflammatory eytokines interleukin-6 （IL-6）, tumor necrosis factor-α （TNF-α） and the level of high sensitive C reactive protein（hs-CRP） before and after treatment were also recorded and compared. And then adverse reactions of the two groups were compared. Results ： Pulmonary function indexes, VPEF/VE, time of peak ratio, TV and TI/TE of two groups after treatment all improved obviously compared with those before treatment （ P 〈 0.05 ） , with higher improvement in the observation group （ P 〈 0.05 ）. The levels of inflammatory factors IL-6, TNF-α and hs-CRP in the two groups were significantly lower than those before treatment （P 〈 0.01 ）, with more decreasing degree in the observation group （P 〈 0. 01 ）. And there was no significant difference in the incidence of adverse reactions between the two groups（P 〉0.05 ）. Conclu- sion：The application of Qing Jin Zhi Decoction in the treatment of children＇s acute bronchiolitis is more conducive to reduce the body＇s levels of inflammatory factors and improve lung function with more practical effect, safe and reliability, thus having a high clinical reference value.
出处
《中医学报》
CAS
2017年第2期190-193,共4页
Acta Chinese Medicine
基金
陕西省中医药管理局资助项目(13-JC027)
关键词
急性毛细支气管炎
青金栀汤
达峰容积比
达峰时间比
潮气量
吸呼比
白细胞介素-6
肿瘤坏死因子-α
超敏C反应蛋白
acute capillary bronchitis
Qing Jin Zhi Decoction
volume ratio of peak
time of peak ratio
tidal volume
respiratoryratio
inflammatory cytokines interleukin-6
tumor necrosis factor-tx
high sensitive C reactive protein
