摘要
叔胺是多种药物分子和天然产物的重要结构组成部分.可见光促进叔胺C—H官能团化反应近年来受到了广泛的关注,为药物分子、生物碱类天然产物的合成提供了便利.基于光氧化还原催化策略,可见光能够诱导叔胺通过单电子转移(SET)过程产生的亚胺正离子或氨基碳自由基中间体,这些中间体能够参与多种类型的有机反应,实现叔胺C—H官能团化.对近年来光氧化还原催化叔胺C—H研究进行了分类和综述.
The tertiary amine motif is an important structure component of multitudinous natural products and drug molecules. Visible light promoted C—H functionalization of tertiary amines has recently received much attention and facilitated the synthesis of alkaloids and drug molecules. Based on photoredox catalysis, visible light is able to induce the formation of iminium cations or α-amino carbon radicals through single electron transfer process which can participate in multitudinous type of organic reactions and complete C—H functionalization of tertiary amines. In this review, the research progress of photoredox catalytic C—H functionalization was categorized and summarized.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第1期1-19,共19页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.31402109)资助项目~~
关键词
叔胺
可见光
光氧化还原催化
C—H官能团化
tertiary amines
visible light
photoredox catalysis
C—H functionalization
