摘要
自噬是机体保守的自我防御机制,是将细胞内变形坏死的细胞器和多余蛋白降解为小分子,以供循环利用。自噬在生理和病理状态下均发挥重要作用,可通过多条信号通路影响胞内物质的表达。目前已知Ras/Raf/MEK/ERK信号通路不仅广泛参与调控细胞生长、增殖、分化、凋亡等多个生理病理过程,并且参与调控自噬,并具有促进肿瘤细胞发生自噬性死亡的作用,但是其具体参与调控自噬的作用机制尚未完全阐明。本文就Ras/Raf/MEK/ERK信号通路参与调控自噬的作用的研究进展进行详细阐述,以期为研究Ras/Raf/MEK/ERK信号通路调控自噬的作用机制提供参考。
Autophagy is a conserved self-defense mechanism of organism,degrading the necrotic organelles and excess protein into small molecules for recycling.Autophagy plays a role in both physiological and pathological condition,influencing the expression of intracellular substance through multiple signaling pathways.Although it has been demonstrated that Ras/Raf/MEK/ERK signaling pathway was not only extensively involved in the regulation of cell growth,proliferation,differentiation and apoptosis,but was also implicated in autophagy and autophagic cell death,though its detailed mechanisms involved in regulation of autophagy has not been fully elucidated yet.This review focused on the advances of autophagy induced by Ras/Raf/MEK/ERK signaling pathway,to better understand the role of Ras/Raf/MEK/ERK signaling pathway in regulation of autophagy.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2017年第1期110-116,共7页
Journal of China Pharmaceutical University
基金
新世纪优秀人才计划资助项目(No.NCET-12-0975)
教育部回国留学人才启动项目资助项目
江苏省新药筛选重点实验室自主探索项目资助项目(No.JKLDS2015ZZ-8)~~
