摘要
目的探索IKBKAP基因多态性及单体型与肺癌易感性的关联。方法采用病例对照研究,使用飞行时间质谱法对IKBKAP SNPs进行基因分型。运用非条件Logistic回归分析探究SNPs与肺癌易感性的关联。应用R软件运行Haplo.stats程序包,分析单体型与原发性肺癌的关联。结果携带rs2230793 CC基因型者发生原发性肺癌的危险是AA+AC携带者的1.386倍(95%CI:1.007~1.907)。经一般人口学特征校正后,rs1538660 TT基因型者发生原发性肺癌的危险是携带CC基因型的0.713倍(95%CI:0.515~0.986);携带rs1538660 TT基因型发生原发性肺癌的危险是携带CC+CT基因型的0.724倍(95%CI:0.530~0.988)。rs1538660、rs3204145 TA单体型携带者的原发性肺癌风险是CT携带者的0.862倍(95%CI:0.753~0.987)。结论 IKBKAP基因多态性与原发性肺癌的发生有关。
Objective To investigate the association between polymorphisms and haplotypes of IKBKAp and the risk of developing lung cancer. Methods Case control Study was condueted to recruit subjects, and MALDI-TOF was employed to determine the genotype of SNPs in IKBKAP gene. The unconditional Logistic regression was performed to analyze the association between selected lung cancer susceptibility and SNPs. The Haplo. stats package of R software was used to investigate the association between haplotypes and lung cancer risk. Results Comparing with the carriers of AA and AC genotype of rs2230793, the OR for those with CC genotype was 1.386（95%＋ CI： 1.00%-1. 907 ）. after adjustment for demo- graphic characteristics, the TT genotype of rs1538660 demonstrated a reduced lung cancer risk with an adjusted OR of 0. 713 （95% CI：0. 515-0. 986） when comparing with CC genotype. Similarly, the TT genotype of rs1538660 was also as- sociated with reduced lung cancer risk when comparing with the carriers with CC and CT genotype with an adjusted OR of 0. 724 （95% CI：0. 530-0. 988）. The carriers of TA haplotype consisted by rs1538660 and rs3204145 demonstrated a re- duced lung cancer risk with an OR of 0. 862 （95% CI：0. 753-0. 987）. Conclusions The polymorphisms in IKBKAP gene may be associated with lung cancer risk.
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第2期136-140,共5页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81172766
81402738)
福建省卫生计生委青年科研项目(2014-1-37)
关键词
肺癌
病例对照研究
多态性
单核苷酸
Lung neoplasms
Case-control studies
Polymorphism, single nucleotide
