摘要
目的探讨宫颈癌经新辅助化疗后的超声造影参数变化特点,及其临床应用价值。方法选取2015年1月至2016年3月期间.因临床确诊为宫颈癌而接受新辅助化疗的45例患者进行分析研究,并根据宫颈癌经新辅助化疗后效果的不同,分为新辅助化疗有效组(A组。35例)和新辅助化疗无效组(B组,10例)。两组患者化疗前后均进行超声造影,测量并记录化疗前后的超声造影参数并作比较分析。结果与化疗前比较,A组宫颈癌病灶经化疗后最大径线明显减小,差异有统计学意义(P〈0.05);与化疗前比较,A组宫颈癌痛灶经化疗后病变造影剂的到达时间(AT)、达峰时间(TTP)明显增大,差异有统计学意义(P〈0.05);与化疗前比较,A组宫颈癌病灶经化疗后峰值强度(PI)明显减小,差异有统计学意义(P〈0.05);与化疗前比较,B组宫颈癌病灶经化疗后最大径线、PI略有增大,而AT、TTP略有减小,但差异均无统计学意义(P〉0.05)。结论宫颈癌病灶经新辅助化疗后形态大小以及血流灌注状态可发生改变,而超声造影可准确定量地监测其改变,为宫颈癌的临床治疗提供参考。
Objective To investigate the parameters change characteristics of contrast-enhanced ultrasound in cervical cancer after neoadjuvant chemotherapy, and its clinical value. Methods Selected 45 patients with cervical cancer who treated with NACT in our hospital in January 2015-March 2016, according to the effect ofNACT, divided into effective group ( group A, 35 cases ) and invalid group ( group B, 10 cases ) . Two groups were performed with CEUS before and after NACT, analysis of the CEUS parameters before and after NACT. Results Compared with before NACT, cervical lesions maximum diameter after NACT in group A significantly reduced ( P〈0.05 ) ; AT, TTP obviously increased ( P〈0.05 ) ; PI obviously decreased ( P〈0.05 ) ; Compared with before NACT, cervical lesions maximum diameter, PI after NACT in group B slightly increased, and AT, TTP slightly reduced ( P〉0.05 ) . Conclusions The shape size and blood flow perfusion status of cervical lesions after NACT can be changed, and CEUS can accurately quantitative monitor the change, provide reference for clinical treatment of cervical cancer.
出处
《浙江临床医学》
2017年第2期306-308,共3页
Zhejiang Clinical Medical Journal
关键词
超声造影
宫颈癌
新辅助化疗
疗效
Contrast-enhanced ultrasound Cervical cancer Neoadjuvant chemotherapy effect