摘要
目的探讨血乳酸、降钙素原以及N末端脑钠肽前体联合检测对脓毒症及感染性休克预后评估的临床价值。方法选取2013年2月-2016年2月医院收治的脓毒血症患者118例,依据患者的病情程度分为脓毒症组39例,严重脓毒症组52例,感染性休克组27例,对3组患者不同时间血乳酸、降钙素原以及N末端脑钠肽前体水平的变化进行比较分析,并对脓毒症患者生存组与死亡组血乳酸、降钙素原以及N末端脑钠肽前体水平进行比较和分析。结果与脓毒症组患者相比,严重脓毒症组和感染性休克组患者在不同时间血乳酸、降钙素原以及N末端脑钠肽前体水平均明显提高,差异均有统计学(P<0.05),与严重脓毒症组患者相比,感染性休克组患者在不同时间血乳酸、降钙素原以及N末端脑钠肽前体水平均明显提高,差异均有统计学意义(P<0.05);与生存患者相比,死亡患者血乳酸、降钙素原以及N末端脑钠肽前体水平均明显提高,差异均有统计学意义(P<0.05)。结论血乳酸、降钙素原以及N末端脑钠肽前体的联合检测对脓毒症和感染性休克患者预后的评估具有重要的临床指导意义。
OBJECTIVE To investigate the clinical value of combined detection of blood lactate,procalcitonin and Nterminal brain natriuretic peptide for prognostic evaluation in sepsis and septic shock.METHODS A total of 118 sepsis patients from Feb.2013 to Feb.2016 were selected in our hospital.According to the severity of the patients,they were divided into sepsis group（n=39）,severe sepsis group（n=52）,and septic shock group（n=27）.The levels of blood lactate,procalcitonin and N-terminal brain natriuretic peptide at different time in the three groups were compared and analyzed.The levels of blood lactate,procalcitonin and N-terminal brain natriuretic peptide of survival group and death group were compared and analyzed.RESULTS Compared with sepsis group,the levels of blood lactate,procalcitonin and N-terminal brain natriuretic peptide in severe sepsis group and septic shock group at different time were increased significantly（P〈0.05）.Compared with severe sepsis group,the levels of blood lactate,procalcitonin and N-terminal brain natriuretic peptide in septic shock group at different time were increased significantly（P〈0.05）.In addition,compared with survival group,the levels of blood lactate,procalcitonin and N-terminal brain natriuretic peptide in death group were increased significantly（P〈0.05）.CONCLUSIONCombined detection of blood lactate,procalcitonin and N-terminal brain natriuretic peptide has very important clinical guiding significance for prognostic evaluation in sepsis and septic shock.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第3期543-545,553,共4页
Chinese Journal of Nosocomiology
基金
河南省杰出人才创新基金资助项目(0623136921)
关键词
脓毒症
感染性休克
预后
血乳酸
降钙素原
N末端脑钠肽前体
Sepsis
Septic shock
Prognosis
Blood lactate
Procalcitonin
N-terminal brain natriuretic peptide
