摘要
目的通过分析某医院中铜绿假单胞菌菌株的临床分布情况及耐药情况,为医院临床治疗用药提供依据。方法将2015年医院各科室送检的标本检测出有铜绿假单胞菌的,进行培养和用K-B纸片扩散法进行药敏试验,并结合2013年和2014年的药敏试验资料进行分析。结果2013~2015年中铜绿假单胞菌在医院中在以呼吸科和ICU的分布最广。而三年中铜绿假单胞菌对氨曲南、头孢他定、头孢噻肟、头孢吡肟、庆大霉素、环丙沙星、哌拉西林、哌拉西林/三唑巴坦、妥布霉素的耐药性呈不同程度地上升,而对丁胺卡那霉素和头孢曲松这两种抗生素的耐药性呈下降趋势。结论铜绿假单胞菌临床分离菌株多来自呼吸科和ICU这两个科室,其对多种抗生素耐药。铜绿假单胞菌的耐药机制主要是该菌外膜通透性极低、或存在主动外排泵排出抗菌药物、或产生多种水解抗生素的酶。临床应加强对铜绿假单胞菌耐药性的监控,并防止耐药菌株的传播流行。
OBJECTIVE To provide information for clinical medication through comprehending the distribution characters and resistance status of Pseudomonas aeruginosa in clinic in hospital,providing the basis of Clinical therapy for hospitals. METHODS The samples from the departments of hospital in 2015 were separated and cultured,susceptibility testing by K-B disk diffusion method. And Analysis Combining the Susceptibility test data of 2013 and2014. RESULTS The most widely distributed departments of Pseudomonas aeruginosa were Respiratory and ICU from 2013 to 2015. The drug tolerance of aztreonam,ceftazidime,cefotaxime,cefepime,gentamicin,ciprofloxacin,piperacillin,piperacillin / tazobactam,tobramycin was increased to varying degrees in three years,while the drug tolerance of amikacin and ceftriaxone was dropped. CONCLUSION The clinical isolates of Pseudomonas aeruginosa were widely from Respiratory and ICU,and it resistance to many antibiotics. The Resistance mechanisms of Pseudomonas aeruginosa mainly are the low permeability of adventitia; or active efflux pump for discharging antibiotics; or producing enzymes whose hydrolysis of antibiotics. It is necessary to monitor the resistance of Pseudomonas aeruginosa and prevent the spread of the resistant strains.
出处
《海峡药学》
2017年第1期77-79,共3页
Strait Pharmaceutical Journal
关键词
铜绿假单胞菌
抗菌药物
耐药性
Pseudomonas aeruginosa
Antibacterial
Drug resistance
