摘要
目的探讨他汀类药物联合阿司匹林治疗急性缺血性脑卒中的临床疗效。方法选取2014年7月-2016年1月笔者所在医院收治的急性缺血性脑卒中患者84例,随机将患者分观察组与对照组,每组各42例。对照组患者采用肠溶阿司匹林片口服治疗,观察组采用阿司匹林联合阿托伐他汀钙片治疗。观察两组患者NIHSS评分,Barthel指数及血脂水平变化。结果两组患者治疗后NIHSS评分,Barthel指数与治疗前相比,差异均有统计学意义（P〈0.05）,且观察组显著优于对照组（P〈0.05）。两组患者治疗后血脂水平均显著优于治疗前（P〈0.05）,但观察组改善水平显著优于对照组,差异有统计学意义（P〈0.05）。两组治疗期间均未出现严重不良反应,观察组中出现胃肠道反应2例,对照组中出现胃肠道反患者1例,牙龈出血患者2例,均停药后自行恢复,两组患者不良反应发生率无明显统计学差异（P〉0.05）。结论他汀类药物联合阿司匹林治疗急性缺血性脑卒中的具有较好的临床效果,能有效改善患者脑神经功能,降低患者血脂水平及不良反应发生率,值得临床治疗中推广应用。
Objective To explore the clinical efficacy of statins-drugs combined with aspirin in the treatment of acute ischemic stroke. Methods 84 patients with acute ischemic stroke were selected from July 2014 to January 2016. The patients were randomly divided into the observation group and the control group, 42 cases in each group. The control group was treated with enteric Aspirin Tablets, and the observation group was treated with Aspirin combined with Atorvastatin Calcium Tablets. NIHSS score, Barthel index and blood lipid level were observed in the two groups. Results After treatment, the NIHSS scores of the two groups were better than that before treatment, the differences were statistically significant（P〈0.05）, and the observation group was significantly better than the control group（P〈0.05）. The blood lipid levels of the two groups were significantly better than before treatment（P〈0.05）, but the improvement in the observation group was significantly better than that in the control group, the difference was statistically significant（P〈0.05）. There was no serious adverse reaction during the treatment in the two groups. In the observation group, there were 2 patients with gastrointestinal reactions. In the control group, there were 1 patient with gastrointestinal reaction and 2 patients with gingival bleeding. All recovered after withdrawal. There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion Statins combined with aspirin in the treatment of acute ischemic stroke has good clinical effect, can effectively improve the brain function of patients, reduce the incidence of blood lipid levels of patients and adverse reactions. It is worthy of popularization and application in clinical treatment.
出处
《中国医药科学》
2016年第19期87-89,共3页
China Medicine And Pharmacy
