摘要
目的：研究盐酸米诺环素联合替硝唑片辅助根管治疗牙周-牙髓联合病变的临床疗效。方法：选择2013年8月~2016年2月在我院进行根管治疗的牙周-牙髓联合病变患者180例,随机分为两组,两组均采用常规根管治疗,对照组口服替硝唑片,观察组采用盐酸米诺环素联合替硝唑片。治疗后1周复查探诊深度和探诊出血,并于治疗后1个月观察临床疗效和不良反应。结果：治疗1周后,两组的探诊深度和探诊出血均比治疗前得到明显的改善（P〈0.05）,且观察组明显优于对照组（P〈0.05）;治疗1月后,观察组的有效率为91.11%（72/90）,明显高于对照组的78.89%（71/90）（P〈0.05）;其中观察组治疗原发牙周病继发牙髓病的有效率为87.09%（27/31）,原发牙髓病继发牙周病为88.89%（24/27）,合并性病变为96.88%（31/32）,均明显高于对照组的80.00%（24/30）,69.23%（18/26）,85.29%（29/34）（P〈0.05）;两组均出现腹痛、恶心、呕吐等轻微不良反应,停药后症状即可消失,无严重不良反应发生。结论：盐酸米诺环素联合替硝唑片能明显改善牙周-牙髓联合病变的临床症状,提高治疗有效率,且不会增加不良反应,值得应用推广。
Objective： To investigate the clinical effect of Minocycline Hydrochloride Ointment combined with Tinidazole Tabletsauxiliary root canal therapy in treatment of periodontal-endodontic lesions. Methods： Selected 180 cases of patients with periodontal-endodontic lesions who were treated in our hospital from August 2013 to February 2016, divided into two groups randomly, 90 cases in observation group, 90 cases in control group. Two groups all received routine root canal treatment, and the patients in control group were administered with Tinidazole Tablets, and the observation group was administered with Minocycline Hydrochloride Ointment combined with Tinidazole Tablets. The probing depth and probing bleeding were observed 1 week after treatment, the clinical curative effect and adverse reactions were detected 1 month aider treatment. Results： After 1 week of treatment, the probing depth and probing bleeding of both groups were significantly improved than before treatment （P〈0.05）, and it was significantly better in the observation group than that of the control group （P〈0.05）; after 1 month of treatment, the effective rate of the observation group was 91.11% （72/90）, significantly higher than 78.89 % of the control group （71/90） （P〈0.05）; and the effective rate of original periodontal disease secondary to diseases of the dental pulp was 87.09% （27/31） in observation group, and the original pulp disease secondary to periodontal disease was 88.89% （24/27）, merge sexually transmitted diseases was 96.88 % （31/32） in observation group, which was significantly higher than that of the control group with statistical significance （P〈0.05）. During the treatment, the patients in both groups suffered abdominal pain, nausea, vomiting and other minor side effects, after withdrawal these symptoms disappeared without serious adverse reactions. Conclusions： Minocyeline Hydrochloride Ointment combined with Tinidazole Tablets can improve symptoms of periodontal-endodontic lesions significantly, and enhance the treatment efficiency without increasing adverse reactions, is worthy clinical application.
作者
黄迎春
赵洁
宋志盛
徐莎莎
浦逢燕
HUANG Ying-chun ZHAO Jie SONG Zhi-sheng XU Sha-sha PU Feng-yan(Department of Stomatology, Nantong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu, 226001, China Petiodontics, Nanjing Stomatological Hospital Medical School of Nanjing University, Nanjing, Jiangsu, 210008, China)
出处
《现代生物医学进展》
CAS
2016年第36期7110-7112,7189,共4页
Progress in Modern Biomedicine
关键词
盐酸米诺环素
替硝唑片
根管治疗
牙周-牙髓联合病变
Minocycline Hydrochloride Ointment
Tinidazole Tablets
Root canal therapy
Periodontal-endodontic lesions
