摘要
目的分析甲状腺叶切除术治疗不同年龄甲状腺良性肿瘤患者的临床效果。方法行单侧甲状腺腺叶切除术的甲状腺良性肿瘤患者150例，按照其年龄大小将其分成青年组、中年组以及老年组，每组各50例，比较三组患者术后1周，术后1、3、6、12个月的游离三碘甲腺原氨酸（FIB）、游离甲状腺素（FT4）以及促甲状腺素（TSH）水平与术前的差异，并比较术后并发症的发生情况以及生活质量评分差异。结果青年组患者gIB水平术后1周[（3．76±0．98）pmol／L]、1个月[（4．08±1．11）pmoL／L]与术前[（4．99±0．87）pmol／L]比较明显降低（P〈0．05），TSH水平在术后1周以及术后1、3个月与术前比较，差异有统计学意义（P〈0．05）；中年组患者的FT3、FT4以及TSH水平与术前比较，差异无统计学意义（P〉0．05）；老年组患者的FT3水平在术后1周以及1、3个月明显降低，FT4水平在术后1、3、6个月明显降低，TSH水平在术后1周以及1、3、6个月明显增高（P〈0．05）。青年组术后并发症的发生率（8．0％）显著低于老年组（28．O％，P〈0．05）。青年组和中年组患者的术后生活质量与术前比较差异无统计学意义（P〉0．05），但老年组患者术后生理职能、一般健康状况、精力以及精神健康等方面评分，与术前比较明显降低（P〈0．05）。结论甲状腺腺叶切除术治疗不同年龄甲状腺良性肿瘤患者的临床效果较好，但术后甲状腺功能恢复存在差异，尤其老年患者较差。
Objective To research the effect of thyroid lobectomy with different age of benign thyroid tumor patients. Methods Selected 150 benign thyroid tumor patients who underwent thyroid iobectomy were divided into youth group, middle-aged group and elderly group according to their age （50 patients in each group）. Compared the free triiodothyronine（ FT3 ）, free thyroxine（ FT4 ）, thyroid stimulating hormone（TSH） at 1 week, 1,3,6 and 12 months after surgery and before surgery. Observe the incidence of postoperative complications and the quality of life. Results The levels of FT3 at 1 week [ （3.76 ± 0. 98 ） pmol/L], 1 month[ （4.08 ±1.11 ） pmol/L] after surgery in the youth group were lower than preoperative level[ （4.99 ±0.87 ） pmol/L ] （ P 〈 0.05 ）. Compared with pre-operation, the level of TSH at 1 week, 1 and 3 months after surgery were statistically different （ P 〈 0.05 ）. There had no significant difference in levels of FT3, FT4 and TSH of the middle-aged patients compared with pre-operation （ P 〉 0.05 ）. The level of FT3 in elderly group were significantly decreased at 1 week, 1 and 3 months after surgery, and FT4 level was significantly lower in 1,3 and 6 months after surgery, TSH level was significantly higher at 1 week, 1 and 3 months after surgery（ P 〈 0.05 ）. The rate of postoperative complications in the youth group （ 8.0% ） was signifieantly lower than that in the elderly group （ （ 8.0% ） P 〈 0.05 ）. There had no signifi- cant differenee in quality of life whatever before or after surgery in youth and middle-aged groups （ P 〉 0.05 ） , but the scores of physiological function, general health, mental health and energy in the elderly group were significantly lower than before surgery （P 〈 0.05 ）. Conclusion The effects of different ages benign thyroid tumor patients undergo thyroid lobectomy are equally good. But the level of postoperative thyroid function reeovery in different ages are different, for the elderly, which is worse.
作者
臧书源
ZANG Shuyuan.(Department of General Surgery, Yancheng Municipal First People＇s Hospital, Jiangsu 224000, Chin)
出处
《临床外科杂志》
2016年第12期931-933,共3页
Journal of Clinical Surgery
