摘要
目的探讨血清降钙素原（procalcitonin,PCT）和超敏C反应蛋白（high sensitivity C-reactive protein,hsCRP）与非ST段抬高急性冠脉综合征（Non ST-elevation Acute Coronary Syndrome,NSTE-ACS）危险分层的相关性。方法选取2014年6月~2016年6月锡山人民医院心内科住院确诊为NSTE-ACS的患者96例,其中不稳定型心绞痛（unstable agina,UA）52例,非ST段抬高心肌梗死（Non-ST elevation myocardial infarction,NSTEMI）44例。入院后所有研究对象均采用全球急性冠状动脉事件注册（The Global Registry of Acute Coronary Events,GRACE）评分系统进行危险分层,分为低危组（n=34）、中危组（n=32）和高危组（n=30）。另选取同期住院非冠心病患者30例作为对照组。对各组进行PCT和hs-CRP水平检测,比较各组之间的差异,并对各组数据用Pearson相关分析探讨相关性。结果各组间hs-CRP水平对照组、低、中、高危各组之间差异有统计学意义（P〈0.05）,而PCT各组间差异无统计学意义（P均〉0.05）,Pearson相关分析显示hs-CRP与GRACE评分相关,且为正相关（r=0.724,P〈0.01）,PCT与GRACE评分相关性无统计学意义（r=0,P〉0.05）。结论 hs-CRP与NSTE-ACS患者GRACE评分显著相关,且为正相关,在临床上可作为NSTE-ACS危险分层的实验室预测指标。PCT与NSTE-ACS患者GRACE评分相关性不明显,对NSTE-ACS危险分层预测依据不充分。
Objective To investigate the relationship between serum procalcitonin（ PCT）,high sensitivity C-reactive protein（ hs-CRP） and non-ST-segment elevation acute coronary syndrome（ NSTE-ACS） risk stratification. Methods 96 patients with NSTE-ACS diagnosed in the Department of Cardiology,Xishan People＇s Hospital from June,2014 to June,2016 were selected,including 52 cases with unstable agina（ UA）,44 cases with non-ST elevation myocardial infarction（ NSTEMI）. All subjects were enrolled in the risk stratification system using the Global Registry of Acute Coronary Events（ GRACE） scoring system,and were divided into low risk group（ n = 34）,moderate risk group（ n = 32） and high-risk group（ n = 30）. Another 30 patients without coronary heart disease were selected as the control group. The levels of PCT and hs-CRP were measured in each group. The differences between the groups were compared and the data were analyzed by Pearson correlation analysis. Results The levels of hs-CRP in each group were significantly different（ P 0. 05） between the control group,low-risk group,moderate and high risk group. While there was no significant difference between PCT groups（ P 0. 05）. Pearson correlation analysis showed that hs-CRP had a positive correlation with GRACE score（ r =0. 724,P 0. 01）,but there was no significant correlation between PCT and GRACE scores（ r = 0,P 0. 05）. Conclusion Hs-CRP was significantly correlated with GRACE score of NSTE-ACS patients and positively correlated,which could be used as a predictor of NSTE-ACS risk stratification clinically. There was no significant correlation between PCT and GRACE scores in patients with NSTE-ACS,and the prediction of NSTE-ACS risk stratification was not sufficient.
作者
黄勇先
郭俊瑾
朱晓明
徐艳
Huang Yongxian Guo Junjin Zhu Xiaoming Xu Yan(Department of Cardiology, Xishan People＇s Hospital, Wuxi , Jiangsu 214011)
出处
《辽宁医学杂志》
2016年第6期32-35,共4页
Medical Journal of Liaoning
