摘要
目的探讨血清肿瘤标志物神经元特异性烯醇化酶（NSE）、癌胚抗原（CEA）、细胞角蛋白19片段（CYFRA21-1）与高尔基蛋白73（GP73）在肺癌诊断中的临床价值。方法选取58例肺癌患者，分为鳞癌、腺癌和小细胞肺癌（SCLC）三组，采用电化学发光法检测各组间与24例肺良性疾病和39例健康体检者血清中的NSE、CEA和CYFRA21-1水平，采用酶联免疫吸附法（ELISA）检测其血清中GP73的水平，并对结果进行统计学分析。结果肺癌组CEA、NSE、CYFRA21-1和GP73含量均高于肺良性病变组和正常组（P〈0.05）。GP73的含量在肺腺癌中最高，敏感度为88.21%；NSE的含量在小细胞肺癌（SCLC）中升高最为明显，敏感度为83.07%；CYFRA21-1以肺鳞癌增高为主，敏感度为80.00%。四项血清肿瘤标志物在肺癌检测中的敏感性依次为GP73（72.31%）、CYFRA21-19（51.29）、CEA（48.67%）、NSE（39.76%）；GP73、CEA、NSE和CYFRA21-1检测肺癌的ROC曲线下面积（AUC）依次为0.892±0.042，0.852±0.050，0.763±0.061，0.691±0.067。结论NSE对SCLC，CYFRA21-1对鳞癌，CEA对肺癌均有较大的辅助诊断价值，但是GP73对肺癌的诊断效能最高，对其进行监测可以有利于肺癌的早期诊断。
ObjectiveTo observe the value of neuron-specific enolase（NSE）, carcinoembryonic antigen （CEA）, cytokeratin 19 fragment （CYFRA21-1）and Golgiglycoprotein73（GP73） in the diagnosis of lung cancer.
MethodsFifty-eight lung cancer patients were selected and divided into three groups of squamous cell carcinoma, adenocar-cinoma and small cell lung carcinoma （SCLC）. The levels of CEA, NSE, CYFRA21-1 were detected and analyzed in the three groups and benign lung disease and healthy persons by electrochemiluminescence inmunoassay. Enzyme linked immunosorbent assay （ELISA） was used to detect the level of GP73 in the blood, and the results were statistically analyzed.ResultsThe serum tumor markers in lung cancer group were significantly higher than those in benign lung disease group and normal group （P〈0.05）; the CEA level in benign lung disease group was higher than that in the normal group. The content of GP73 was the highest in lung cancer group, the sensitivity was 88.21%. Elevated levels of NSE in SCLC was the most obvious, the sensitivity was 83.07%. Increased CYFRA21-1 was given priority to lung squamous carcinoma, the sensitivity was 80.00%. The sensitivity of the four serum tumor markers in lung cancer detection was 72.31%（GP73）, 51.29% （CYFRA21-19） and 48.67% （CEA）, 39.76% （NSE）; the testing areas under the ROC curve of GP73, CEA, NSE and CYFRA21-1 was 0.892±0.042, 0.852±0.050, 0.763±0.061, 0.691±0.067.ConclusionsNSE for SCLC, CYFRA21-1 for squamous cell carcinomas, CEA for lung cancer has great auxiliary diagnostic value, but GP73 has highest efficiency on the diagnosis of lung cancer, monitoring GP73 can be beneficial to the early diagnosis of lung cancer.
作者
周竞奇
Zhou Jingqi(Jiyuan People＇ s Hospital, Jiyuan 454650, Chin)
出处
《中国实用医刊》
2017年第1期70-73,共4页
Chinese Journal of Practical Medicine
