摘要
目的对比分析三种不同的新辅助化疗方案治疗三阴性乳腺癌的近期临床效果。方法随机选取2013年4月至2015年4月120例三阴性乳腺癌患者，根据新辅助化疗方式的不同分为A、B、C三组，每组40例。A组给予多西他赛、表阿霉素和环磷酰胺治疗，B组给予环磷酰胺、多西他赛治疗，C组给予氟尿嘧啶、表阿霉素、环磷酰胺治疗，对比分析三组化疗后的近期疗效和临床不良反应情况。结果A组近期疗效有效率为87.5%，B组为85.0%，C组为82.5%，且A组明显高于B、C组，差异有统计学意义（P〈0.05）；三组部分缓解、完全缓解及总有效率比较差异未见统计学意义（P〉0.05）；化疗第3周A、B组缩小情况明显优于C组，差异有统计学意义（P〈0.05）。结论采用多西他赛、表阿霉素和环磷酰胺治疗三阴性乳腺癌患者的近期治疗效果优于采用环磷酰胺、多西他赛和采用氟尿嘧啶、表阿霉素、环磷酰胺的治疗方案，能延长患者无病生存时间，提高其生存率，且治疗中未发现因药物导致的过敏反应，值得临床研究推广。
ObjectiveThe compare the short-term therapeutic effect of three different neoadjuvant chemotherapy regimens on triple negative breast cancer（TNBC）.MethodsFrom April 2013 to April 2015, 120 patients with TNBC were randomly selected, according to the different wasy of neoadjuvant chemotherapy, the patients were divided into group A, group B and group C, with 40 cases in geach group. The patients in group A were treated with docetaxel, epirubicin and cyclophosphamide（TAC）, and the patients in group B were treated with docetaxel and cyclophosphamide （TC）, and the patients in group C were treated with 5-fluorouracil, epirubicin, cyclophosphamide （CEF）, the curative effects and clinical adverse reactions of three groups of patients after chemotherapy were analyzed.ResultsThe efficacy rate was 87.5% in group A, which was significantly higher than that in group B（85.0%） and group C（82.5%）, the differences were statistically significant （P〈0.05）; there were no significant differences in PR, RR, CR among the three groups（P〉0.05）; after chemotherapy for three weeks, the tumor size decreased in group A and group B was significantly higher than that in group C, the difference was significant （P〈0.05）.ConclusionsThe short-term therapeutic effect of docetaxel, epirubicin and cyclophosphamide on TNBC is better than docetaxel and cyclophosphamide, fluorouracil, epirubicin, cyclophosphamide, it can prolong the disease-free survival time of patients, improve the survival rate, no allergic reactions induced by drugs are found in the treatment, it is worthy of clinical research.
作者
丁权
Ding Quan(Department of Medical Oncology, the First People＇ s Hospital of Zhumadian, Zhumadian 463000, Chin)
出处
《中国实用医刊》
2017年第1期35-37,共3页
Chinese Journal of Practical Medicine
关键词
三阴性乳腺癌
近期疗效
新辅助化疗方案
不良反应
Triple negative breast cancer
Short-term effect
Neoadjuvant chemotherapy
Adverse reactions
