摘要
目的探索血浆置换（PE）和双重血浆置换（DFFP）对高脂血症性重症急性胰腺炎（HSAP）患者三酰甘油清除率及并发症的影响，为临床治疗提供参考。方法回顾性分析40例高脂血症性重症急性胰腺炎患者的临床资料，按照血浆置换、双重血浆置换治疗分为两组，每组20例，比较两组患者三酰甘油清除率、并发症发生情况及治疗效果。结果血浆置换组不同时段三酰甘油清除率分别为36.1%、66.0%和84.9%，而双重血浆置换组不同时段三酰甘油清除率分别为51.9%、81.0%和90.2%，明显高于同时段血浆置换组的血清三酰甘油清除率，差异有统计学意义（P〈0.05）；血浆置换组出现输血浆相关并发症7例，而双重血浆置换组出现1例，差异有统计学意义（P〈0.05）。结论血浆置换与双重血浆置换均可有效降低高脂血症性重症急性胰腺炎患者的血清三酰甘油浓度。两者比较，双重血浆置换清除速率更快，且除呼吸衰竭并发症二者相同外，其余并发症均明显少于血浆置换。
ObjectiveTo investigate the effect of plasma exchange and double plasma exchange on serum triglyceride clearance and complications in patients with severe acute pancreatitis.MethodsThe clinical data of 40 patients with severe acute pancreatitis were analyzed retrospectively, according to the plasma exchange treatment, the patients were divided into two groups, with 20 cases in each group, the glycerol triacetate （ester） clearance rates, complications and therapeutic effects were compared.ResultsThe glycerol triacetate （ester） clearance rate of double plasma exchange group in different periods were 51.9%, 81.0% and 90.2%, which were significantly higher than those of the plasma exchange group （36.1%, 66.0% and 84.9%）, the differences between the two groups were significant （P〈0.05）; the plasma transfusion related complications occurred in 7 cases in plasma exchange group, and double plasmapheresis group had 1 case, there was significant difference （P〈0.05）.ConclusionsPlasma exchange and double plasma exchange can effectively reduce the serum triglyceride concentration in patients with hyperlipidemia. In comparison, the double plasma exchange rate is faster, and the other complications of double plasma exchange are significantly lower than those of plasma exchange except the respiratory failure.
作者
刘学进
Liu Xuejin(Department of Gastroenterology, Zhoukou Central Hospital, Zhoukou 466000, Chin)
出处
《中国实用医刊》
2017年第1期30-32,共3页
Chinese Journal of Practical Medicine
