摘要
了解HBeAg、HBV -DNA及前S1抗原相关性及其临床意义。采用ELISA法检测HBV标志物 ,PCR法检测HBV -DNA。 196例不同模式HBV感染者血清HBV -DNA及前S1抗原的总检出率分别为 38 78%和4 0 30 % ,二者无明显差异 (P >0 0 5 )。其中 4 4例HBeAg阳性模式感染者HBV -DNA和前S1抗原的检出率分别为 88 6 4 %和 86 36 % ,两者无明显差异 (P >0 0 5 )。 15 2例不同模式HBeAg阴性感染者HBV -DNA和前S1抗原的检出率分别为 2 4 34%和 2 6 97% ,明显低于HBeAg阳性模式的检出率 ,二者有显著性差异 (P <0 0 5 )。结论 :HBeAg、HBV -DNA及前S1抗原间有着密切的相关性。前S1抗原是病毒复制的又一新标志 ,且与病程的发展及疗效的观察有着重要的意义。
To investigate analysis of the relationship and clinical sense among HBeAg?HBV-DNA and pre-S 1 antigen, They were detected by PCR and EL1SA. The total detection rate of HBV-DNA and Pre-S 1antigen in 196 cases with different mould were 38 78%(76/196) and 40 30% 79/ 196). The detection rate of HBV-DNA and Pre-S 1 antigen in 44 Cases HBeAg Positive Patients were 88 64% (39/44) and 86 36% (38/44). The detecfion rate of HBV-DNA and Pre-S 1 anfigen in 152 cases HBeag negative patients were 24 34% (37/152) and 26 97%(41/152). There was a close relationship among HBeAg?HBV-DNA and Pre-S 1 antigen.
出处
《临床肝胆病杂志》
CAS
北大核心
2002年第4期217-218,共2页
Journal of Clinical Hepatology
