摘要
剥脱综合征（exfoliationsyndrome，XFS）是一种与年龄相关的、迟发性、多因素参与的系统性疾病，是继发性开角型青光眼的主要原因之一。XFS发病与遗传因素和环境因素有关，但具体发病机制尚未阐明。本文将近年来XFS发病机制研究进展进行总结，从LOXL1基因多态性、基因甲基化、环境因素、自噬等可能参与XFS形成和发展多方面进行阐述，以利于XFS的防治。
Exfoliation syndrome （ XFS）, one of the most common causes of secondary glaucoma, is an age-related, late-oneset, multifactorial systemic disease. The pathogenesis involves both genetic and envi- ronmental factors. However, the exact pathogenesis of XFS is still unclear. The purpose of this article was to review the progress of pathogenesis research in XFS, including the aspects of LOXL1 genetic polymorphism, gene hypermethylation, environmental factors, autophagy and so on, which may be involved in the formation and development of XFS. It can deepen the understanding of XFS, expecting to contribute to the prevention and treatment of XFS.
出处
《国际眼科纵览》
2016年第6期380-383,共4页
International Review of Ophthalmology
关键词
剥脱综合征/病理生理学
基因
环境
自噬
exfoliation syndrome/pathophysiology
genes
environmental factors
autophagy
