摘要
目的探讨女性年龄对胚胎植入前遗传学诊断及筛查(PGD/PGS)结局的影响。方法回顾性分析2015年1月1日至12月31日开展PGD/PGS治疗周期的149例患者,按女性年龄将患者分为3组:Ⅰ组10例(<25岁)共36枚囊胚;Ⅱ组94例(25~34岁)共329枚囊胚;Ⅲ组45例(≥35岁)共89枚囊胚。比较各组之间的胚胎正常率和临床妊娠率。结果Ⅰ组、Ⅱ组、Ⅲ组的胚胎正常率分别为50.00%、50.15%、29.21%。Ⅰ组与Ⅲ组的胚胎正常率比较差异有统计学意义(χ~2=4.855,P<0.05),Ⅱ组与Ⅲ组的胚胎正常率比较差异有统计学意义(χ~2=12.376,P<0.05)。Ⅰ组、Ⅱ组、Ⅲ组的临床妊娠率分别为83.33%、82.50%、40.00%。Ⅰ组与Ⅲ组的临床妊娠率比较差异有统计学意义(χ~2=3.893,P<0.05),Ⅱ组与Ⅲ组的临床妊娠率比较差异有统计学意义(χ~2=7.510,P<0.05)。结论女性年龄对PGD/PGS结局有影响,当女性年龄≥35岁时会明显降低胚胎的正常率和临床妊娠率。
Objective To investigate the female effects of age on the outcome of preimplantation genetic diagnosis and screening（ PGD/PGS）. Methods Clinical data of 149 patients who received PGD/PGS in our hospital during Jan.and Dec. 2015 were retrospectively reviewed. The patients were divided into 3 groups according to age： group Ⅰ（ n =10, 25 years,36 blastocysts）,group Ⅱ（ n = 94,25-34 years,329 blastocysts）,and group Ⅲ（ n = 45,≥35 years,89 blastocysts）. The normal chromosome rate and clinical pregnancy rate of the three groups were compared. Results The normal chromosome rate in groups Ⅰ,Ⅱ and Ⅲ was 50. 00%,50. 15% and 29. 21%,respectively. There were statistical differences between groups Ⅰ and Ⅲ（ χ^2= 4. 855,P〈0. 05）,and groups Ⅱ and Ⅲ（ χ^2= 12. 376,P〈0. 05）. The clinical pregnancy rate in groups Ⅰ,Ⅱ and Ⅲ was 82. 33%,82. 50% and 40. 00%,respectively. There were statistical differences between groups Ⅰ and Ⅲ（ χ^2= 3. 893,P〈0. 05）,and groups Ⅱ and Ⅲ（ χ^2= 7. 510,P〈0. 05）. Conclusion The female age can affect the outcome of PGD/PGS. Age ≥35 years will significantly reduces the normal chromosome rate and clinical pregnancy rate.
作者
李昀
仲万霞
姚宁
胡双纲
刘洪卯
LI Yun ZHONG Wanxia YAO Ning HU Shuanggang LIU Hongmao(Center for Reproductive Medicine, Renji Hospital, Medical School of Shanghai Jiaotong University,Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China)
出处
《山东大学学报（医学版）》
CAS
北大核心
2017年第1期60-62,68,共4页
Journal of Shandong University:Health Sciences
关键词
女性年龄
囊胚活检
植入前遗传学诊断及筛查
胚胎正常率
临床妊娠率
Female age
Blastocyst biopsy
Preimplantation genetic diagnosis and screening
Normal chromosome rate
Clinical pregnancy rate
