摘要
病毒载体与非病毒载体是目前最常使用的两大类基因转运载体。虽然病毒载体,如腺病毒、慢病毒等转染效率更高,但由于存在细胞毒性、潜在致突变性及较高的免疫原性等的安全问题,使其在临床进一步应用受到很大的限制。非病毒载体,如天然多糖聚合物、阳离子聚合物、脂质体、无机纳米载体等具有结构简单、制备过程可控、低免疫原性等优点。本文主要就非病毒基因载体的研究进展进行综述。
Viral vectors and non-viral vectors are the two most commonly used gene delivery carriers at present.Al- though viral vectors, such as adenovirus and lentivirus have higher transfection efficiency, the security problems of cell toxicity and potential mutagenicity and high immunogenicity restrict them from further clinical application.Non-viral vectors, such as natural polysaccharide polymers, cationic polymers, liposomes and inorganic nano-carriers have the advantages of simple structure,controllable preparation process,low immunogenicity and so on.This article reviews the research progress of non-viral gene vectors.
出处
《中国疗养医学》
2017年第2期134-136,共3页
Chinese Journal of Convalescent Medicine
基金
青岛市市南区公共领域科技支撑计划项目(2014-14-047-SW)
关键词
基因
载体
综述
Gene
Vector
Review
