摘要
目的 探讨碱性成纤维细胞生长因子 (bFGF)及转化生长因子 β1(TGFβ1)在乳腺癌中的表达及临床意义。方法 以人乳腺癌组织为恶性肿瘤标本模型 ,乳腺纤维腺瘤为良性肿瘤标本模型 ,免疫组织化学染色观察bFGF与TGFβ1的表达。结果 乳腺癌组织中bFGF、TGFβ1平均阳性细胞率明显高于乳腺纤维瘤组织 (P <0 0 5 )。结论 bFGF与TGFβ1在乳腺癌发病发展过程中起重要促进作用 ,bFGF与TGFβ1表达是乳腺癌预后不良因素之一 。
Objctive To study the expression and clinical significance of basic fibroblast growth facfor(bFGF) and transforming growth factor (TGF β 1) in human breast carcinoma.Methods Human breast carcinoma tissuess were studied as malignant tumor model,human breast fibroma tissue were studied as benign tumor model,and expression of bFGF and TGF β 1 were observed by immunohistochemistry staining.Results The positive cell rate in breast carcinoma was higher than that in breast fibroma(P<0.05).Conclusions bFGF and TGF β 1,play an important promoting role in the formation process of breast carcinoma,and their positive expression is one of ominous factors in prognosis of human breast carcinoma.bFGF and TGF β 1 can be a new index for prognosticating human breast carcinoma.
出处
《武警医学》
CAS
2002年第8期457-459,共3页
Medical Journal of the Chinese People's Armed Police Force
