摘要
维生素D除参与调节体内钙磷代谢外，其缺乏与全身和神经系统的多种疾病的发病密切相关，如多发性硬化、阿尔茨海默症、帕金森病和脑血管疾病等。近年来研究发现维生素D可能在癫痫的发病机制中起着重要作用，并可能具有一定的抗惊厥作用。该文对维生素D在癫痫中的作用，血清维生素D水平及其受体基因的多态性与癫痫的关系进行了综述，也总结了抗癫痢药和维生素D之间的相互作用。
Vitamin D adjusts the body＇s absorption and utilization of calciumand phosphorus. Vitamin D deficiency is closely related to incidence of many disease. Several disorders, both systemic and those of the nerv- ous system, have been linked with vitamin D deficiency. Neurological disorders with a vitamin D link include but are not limited to multiple sclerosis, Alzheimer and Parkinson disease, as well as cerebrovascular disorders. In re- cent years, studies have found that the vitamin D may play a critical role in the pathogenesis of epilepsy and pos- sess certain anticonvulsant effects. This article summarized the role of vitamin D in the nervous system and epi- lepsy, the level of serum vitamin D and the correlation of the polymorphism of its receptor genes with epilepsy. The review also summarizes the interaction between antiepileptic drugs and vitamin D.
出处
《国际儿科学杂志》
2016年第12期948-952,共5页
International Journal of Pediatrics
