摘要
随着低出生体重儿存活率的提高，早产儿脑损伤成为热点问题，损伤部位不仅局限于脑白质，灰质区域也有受累，故提出了“早产儿脑病”的概念。早产儿脑病包括脑白质损伤和神经元轴突病变。在缺血缺氧、围生期感染等致病因素作用下，脑组织发生直接或间接的神经细胞死亡或者是成熟障碍，最终导致脑性瘫痪、认知、语言、行为等能力障碍。该文总结了早产儿脑病的病理、发病机制、治疗及预后等情况。
With the increased survival of the low birth weight,brain injury in the premature infants be- comes a problem of enormous importance. The introduction of the term ＂encephalopathy of prematurity＂ is the current recognition that preterm brain injury is a complex of white and gray matter damage. The combination of white matter injury and neuronal/axonal deficits constitutes encephalopathy of prematurity. The preterm infants develop primary destructive brain lesions, secondary degeneration and disturbance of maturation from hypoxia-ischemia and inflammation, which leads to cerebral palsy, cognitive, behavioral, or language deficits. This article reviews the neuropathology, pathogenesis, therapy and neurodevelopmental disability of encephalopathy of pre maturity.
出处
《国际儿科学杂志》
2016年第12期909-912,共4页
International Journal of Pediatrics
关键词
早产儿脑病
少突胶质前体细胞
神经元
发育障碍
Encephalopathy of prematurity
Premyelinating oligodendrocyte
Neuron
Dysmaturation
