摘要
幽门螺杆菌与许多消化系统疾病如慢性胃炎、消化性溃疡、胃黏膜相关淋巴样组织淋巴瘤和胃癌密切相关，还可导致儿童缺铁性贫血、生长障碍、哮喘、过敏性疾病等，而根除幽门螺杆菌是防治这些疾病的重要措施。近年来，随着克拉霉素及甲硝唑耐药率逐渐上升，标准三联疗法根除率已小于80％，远远达不到临床要求。特别是克拉霉素高耐药地区，标准三联疗法已不能被推荐作为一线治疗，需探讨新的治疗对策以提高幽门螺杆菌的根除率。儿童中根除幽门螺杆菌新的治疗方案主要有序贯疗法、含铋剂疗法、伴同疗法及联合益生菌等。该文就近年国内外对上述新方案的研究进展作一综述。
Helicobacter pylori is closely related to many digestive system diseases, such as chronic gas- tritis, digestive ulcer, gastric mucosa associated lymphoid tissue lymphoma and gastric cancer, also leads to chil- dren with iron deficiency anemia, growth retardation, asthma,allergic diseases etc. So it is a key strategy to pre- vent and treat these diseases by eradicating Helicobacter pylori. Due to the increasing rates of antimicrobial resist- ance of clarithromycin and metronidazole,the eradication rate of standard aiple therapy is less than 80% in re- cent years. Especially in areas of high clarithromycin resistance and standard triple therapy have not been recom- mended as first-line therapy,it is necessary to investigate a new therapeutic strategy to improve the eradication rate of Helicobacter pylori. The new treatments for eradication of Helicobacter pylori in children is mainly based on sequential therapy, bismuth-based therapy, concomitant therapy and probiotics treatment. This article reviews the research progress of the new treatments in recent years.
出处
《国际儿科学杂志》
2016年第12期905-909,共5页
International Journal of Pediatrics
关键词
幽门螺杆菌
根除率
序贯疗法
含铋剂疗法
伴同疗法
益生菌
Helicobacter pylori
Eradication rate
Sequential therapy
Bismuth-based therapy
Concomi- tant therapy
Probiotics
