摘要
随着前哨淋巴结活检术成为临床腋窝淋巴结阴性的早期乳腺癌患者的标准处理模式,关于活检示踪剂的研究成为乳腺癌研究的热点之一。目前,临床上应用较多的示踪剂包括蓝染料、核素及二者的结合,但这两种示踪剂存在的某些不足导致发达国家仅有60%的患者进行前哨淋巴结活检,中国仅占约5%,其他发展中国家更少。近年来,各种新型示踪剂的研究层出不穷,如吲哚菁绿、使用微气泡的对比增强超声和超顺磁性氧化铁颗粒等。该文回顾了这三种物质的特性及作为示踪剂的相关研究,这些新型示踪技术仍处于初级研究阶段,有待于进一步实验以便临床应用。
Sentinel lymph node biopsy has been proved to be the standard treatment for early breast cancer patients with negative axillary lymph node. The study related to the tracer has become one of the hottest topics in breast cancer research. At present, the biopsy is often performed using the tracer of isotope, blue dye or both of them. However, some deficiencies of the 2 tracers restrained their applications, which resulted that the rate of the procedure is limited to only about 60% of patients in developed countries and less than 5% of patients in China and other developing countries. In recent years, a variety of new tracers have emerged, such as indocyanine green, contrast-enhanced ultrasound using microbubbles, superparamagnetie iron oxide nanoparticles. In this article, we introduced the characteristics of these 3 substances and reviewed the related research on the new tracers. In conclusion, the new tracers are still in the preliminary stage of research, and further research is needed for clinical application.
作者
李盼盼
王永胜
LI Panpan WANG Yongsheng(Shandong Academy of Medical Science, and School of Medicine and Life Sciences, University of Jinan, Jinan 250200, Shandong Province, China Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, Jinan 250117, Shandong Province, China Shandong Academy of Medical Sciences, Jinan 250062, Shandong Province, China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2016年第12期1031-1036,共6页
China Oncology
基金
国家自然科学基金(81502314
81672638)
山东省自然科学基金(ZR2014HZ003
ZR2015PH025)
