摘要
目的探讨贝前列腺素钠片联合他汀类药物对动脉粥样硬化性心血管疾病(ASCVD)患者血管内皮功能的影响。方法选取2013年10月至2015年9月收治的动脉粥样硬化性心血管疾病老年患者70例,随机分为两组,单用组与联用组,每组各35例。单用组患者仅服用阿托伐他汀进行治疗,联合组患者在单用组的治疗基础上联合使用贝前列腺素钠片,两组患者均持续治疗12周。对比分析两组患者治疗前后的血压和血脂水平、血清内皮素1(ET-1),一氧化氮(NO)、血管性血友病因子(vWF)水平和肱踝脉搏波传导速度(baPWV)。结果两组患者经过治疗后,其血清TG、TC、LDL-C、ET-1和vWF均较治疗前明显降低(P<0.05)且联用组患者SBP、TG、LDL-C、vWF和ET-1明显低于对照组,差异有统计学意义(P<0.05);两组患者的血清NO水平较治疗前明显升高(P<0.05);联用组患者经过治疗后其baPWV明显降低(P<0.05)。结论贝前列腺素钠片联合他汀类药物能够有效地降低ASCVD患者的血脂水平,改善血管内皮功能,延缓动脉粥样硬化进展,在治疗老年ASCVD患者的过程中值得推广应用。
Objective To investigate the effect of beraprost sodium tablet combined with statins on atherosclerotic vascular endothelial function in patients with cardiovascular disease.Methods From October 2013 to September 2015,70 cases of patients with atherosclerotic cardiovascular disease in our hospital were randomly divided into two groups,single group and combination group,35 cases in each group.Single group of patients only taken atorvastatin treatment,the combined group of patients taken beraprost sodium tablet on the basis treatment of single group.Patients were treated for 12 weeks.Blood pressure,lipid levels serum ET- 1,NO,vWF levels and BAPWV before and after treatment of the two groups were compared.Results In two groups of patients after treatment,the serum TG,TC,LDL- C and vWF,was significantly lower than those of before treatment（P〈 0.05）,and SBP,TG,LDL- C,vWF,ET- 1 in combination group were significantly lower than those of single group（P 〈0.05）.Serum NO levels of the two groups increased significantly after treatment（P 〈0.05）.Conclusion Beraprost sodium tablets combined with statin drugs can effectively reduce blood lipid levels in patients,improve endothelial function and delay progression of atherosclerosis.It should be widely applied in the treatment of elderly patients with ASCVD.
出处
《临床和实验医学杂志》
2017年第2期184-187,共4页
Journal of Clinical and Experimental Medicine
关键词
动脉硬化性心血管疾病
贝前列腺素钠
血管内皮功能
Arteriosclerotic cardiovascular disease
Beraprost sodium
Vascular endothelial function
