摘要
目的检测患者血清中脂蛋白(a)、D-二聚体(D-D)、同型半胱氨酸(Hcy)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(LDL)水平,探讨6种指标在脑梗死的临床诊断治疗中的价值。方法分别检测66例脑梗死患者(脑梗死组)和56例健康体检者(对照组)血清中的LP(a)、D-D、Hcy、TC、TG、LDL水平,并进行统计学分析。再选择急性脑梗死患者40例,以初入院检测的LP(a)、D-D、Hcy、LDL血清水平为治疗前组,病情稳定后的检测指标为治疗后组。用SPSS19.0和ROC曲线进行统计分析。结果脑梗死组血清中LP(a)、D-D、Hcy、TC、TG、LDL水平明显高于对照组,并且差异有统计学意义(P<0.01)。治疗前和治疗后两组血清中的LP(a)、D-D、Hcy、LDL水平差异有统计学意义(P<0.05)。运用ROC曲线进行治疗前后的数据分析,发现特异度和灵敏度D-D>Hcy>LP(a)>LDL。结论LP(a)、D-D、Hcy、TC、TG、LDL对脑梗死的监测和疗效评估有着重要的意义。
Objective To investigate the value of detecting the serum levels of LP（a）,D-dimer（D-D）,Hcy,TC,TG and LDL in clinical diagnosis and treatment of cerebral infarction.Methods The serum levels of LP（a）,D-D,Hcy,TC,TG and LDL were detected in 66 cases of cerebral infarction as the cerebral infarction group and 56 individuals undergoing the physical examination as the control group.The two groups were performed the statistical analysis.Then 40 cases of acute cerebral infarction were selected.The serum levels of LP（a）,D-D,Hcy and LDL detected at admission served as the pre-treatment group,while which detected after the stable condition as the post-treatment group.The obtained data were statistically analyzed by using SPSS19.0software and ROC curve.Results The serum levels of LP（a）,D-D,Hcy,TC,TG and LDL in the cerebral infarction group were significantly higher than those in the control group and the difference was statistically significant（P〈0.01）.The levels of LP（a）,D-D,Hcy and LDL had statistical difference between the pre-treatment group and post-treatment group（P〈0.05）.The pre-treatment and posttreatment data analysis by using the ROC curve found that the specificity and sensitivity were D-D〉Hcy〉LP（a）〉LDL.Conclusion Serum levels of LP（a）,D-D,Hcy,TC,TG and LDL have an important significance to monitoring and evaluation of curative effect in cerebral infarction.
出处
《国际检验医学杂志》
CAS
2016年第24期3449-3450,共2页
International Journal of Laboratory Medicine
