摘要
目的：探讨复方甘草酸苷对过敏性紫癜患儿细胞免疫功能及血清中细胞因子水平的影响。方法确诊的60例过敏性紫癜患儿随机数表法均分为观察组和对照组，每组30例。对照组患儿均采用对症治疗及常规护理，观察组患儿采用复方甘草酸苷治疗。观察两组患儿过敏性紫癜症状改善情况、Treg 细胞及Th17细胞转阳率以及 IL-10、IL-12和 IL-1β细胞因子的水平变化。结果经分析比较，观察组的皮疹、腹痛以及关节症状改善有效率分别为93．3％、87．7％及76．7％，优于对照组57．6％、56．7％及50．0％，差异均有统计学意义（χ2＝5．455、6．648、3．890，均 P ＜0．05）；观察组治疗后外周血 Treg 细胞及 Th17细胞比例分别为7．77％和0．46％，优于对照组的6．14％和0．60％，差异有统计学意义（t ＝2．391、2．355，均 P ＜0．05）；观察组治疗后 IL-10、IL-12和 IL-1β细胞因子分别为（46．26±6．37）pg／mL、（117．36±12．76）pg／mL 和（6．69±1．23）pg／mL，均高于对照组的（29．43±4．77）pg／mL、（89．46±8．38）pg／mL、（4．23±1．06）pg／mL，差异均有统计学意义（t ＝11．583、10．010、8．298，均 P ＜0．05）。结论复方甘草酸苷对调节过敏性紫癜患儿细胞免疫功能及血清中细胞因子水平等方面具有一定的促进作用。
Objective To explore the effect of compound glycyrrhizin on the cellular immune function and the levels of cytokines in serum of children with Henoch -Schonlein purpura.Methods 60 cases of allergic purpura were selected and randomly divided into observation group and control group.The control group were treated with symptomatic treatment and routine nursing care,the observation group was treated with compound glycyrrhizin.The improvement of symptoms of the two groups,Treg cell and Th17 cell positive rates,as well as the levels of IL -10, IL -12 and IL -1βbeta were observed.Results After analysis and comparison,the effective rates of rash,abdominal pain and joint symptoms in the observation group were 93.30%,87.70% and 76.70% respectively,which were significantly higher than 57.60%,56.70% and 50.00% in the control group,the differences were statistically signifi-cant （χ2 =5.455,6.648,3.890,all P 〈0.05）.The proportions of Treg cells and Th17 cells in peripheral blood after treatment in the observation group were 7.77% and 6.14%,which were significantly higher than those of the control group （0.60% and 0.46%）,and the differences were statistically significant （t =2.391,2.355,all P 〈0.05）.After treatment,the levels of IL -10,IL -12 and IL -1βbeta in the observation group were （46.26 ±6.37）pg/mL, （117.36 ±12.76）pg/mL,（6.69 ±1.23）pg/mL,which were higher than those of the control group （29.43 ± 4.77）pg/mL,（89.46 ±8.38）pg/mL,（4.23 ±1.06）pg/mL,the differences were statistically significant （t =11.583,10.010,8.298,all P 〈0.05 ）.Conclusion The effect of compound glycyrrhizin on the cellular immune function and the level of cytokines in serum of children with Henoch -Schonlein purpura is good.
作者
胡晓忠
Hu Xiaozhong(Department of Pediatrics, the Peoplels Hospital of Lincang ,Lincang , Yunnan 677000, Chin)
出处
《中国基层医药》
CAS
2016年第24期3760-3764,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
复方甘草酸苷
过敏性紫癜
细胞免疫
细胞因子
Compound glycyrrhizin
Henoch -Schonlein purpura
Cellular immunity
Cytokines
