摘要
目的 探讨成人可逆性胼胝体压部病变综合征（RESLES）的病程特点、影像学表现及实验室生化结果,并对其进行临床分析。方法 通过回顾性分析2013年1月-2016年1月就诊于我院的确诊为成人RESLES的患者7例,对其临床特点、影像学、生化资料、治疗及预后进行分析。结果 7例患者中,4例男性,3例女性,5例有发热、头痛表现,部分病例伴有意识障碍、视物障碍、呕吐等症状。7例患者分别于发病后第3-14天行头部MRI检查,均提示胼胝体压部（SCC）异常信号,病变在T1WI为稍低或低信号,在T2WI及Flair成像为稍高或高信号,在DWI为高信号及ADC为低信号,增强扫描均没有强化效应。针对7例患者病因予以针对性治疗,全部病例于发病后7-60天临床症状完全缓解,于发病后10-45天复查头部MRI提示病灶完全消失。结论 RESLES是一组临床影像学综合征,其病理生理学机制尚不完全明确,病因复杂,表现多样,有特征性影像学表现,针对不同病因进行针对性治疗,预后较好。
Objective To investigate the clinical characteristics, imaging findings and laboratory biochemical results of reversible splenial lesion syndrome （RESLES） in adult patients, and to carry out the clinical analysis. Methods We retrospectively analysed of 7 cases of adult patients whose clinical diagnosis were RESLES and were treated from January 2013 to January 2016 in Shengjing Hospital of China Medical University, and analysed the clinical characteristics, imaging, biochemical data, treatment and prognosis. Results Among the 7 cases, 4 were male, 3 were female, 5 had fever and headache, some cases were accompanied with symptoms such as disturbance of consciousness, visual disturbance, vomiting and so on. 7 cases all underwent head MRI 3 to 14 days after the onset, which showed the abnormal signal of splenium of the corpus callosum （SCC） , slightly low or low signal in T1WI, high or slightly high signal in T2WI and FLAIR, high signal in DWI and low signal in ADC, and no enhancement effect in all enhanced scan. According to the etiology of 7 cases of patients with targeted therapy, clinical symptoms were completely remission in the 7 to 60 days after the onset, the lesion completely disappeared in the 10 to 45 days after the onset by reviewed head MRI. Conclusion RESLES is a group of clinical imaging syndrome, its pathophysiological mechanism is still uncompletely clear, etiology is complex , manifestation is various, but it has characteristic imaging findings, and targeted treatment according to different causes, the prognosis is well.
出处
《医学影像学杂志》
2016年第12期2168-2172,共5页
Journal of Medical Imaging
