摘要
目的探讨急性中毒患者并发横纹肌溶解症(RM)的危险因素。方法回顾性分析195例急性中毒患者的临床资料,根据入院时是否合并RM分为RM组和非RM组,比较2组患者的临床资料,选择有统计学意义的变量(P<0.05)进行多因素Logistic回归分析。结果入选的195例急性中毒患者中,44例并发RM,发生率为22.6%。单因素分析结果显示,2组患者的性别、年龄、血乳酸水平比较差异均无统计学意义(P均>0.05);2组患者在药物种类、血钾、血钠、APACHEⅡ评分、是否合并昏迷、抽搐、感染及缺血缺氧方面比较差异均有统计学意义(P均<0.05)。多因素回归分析结果显示,昏迷、抽搐、缺血缺氧是急性中毒患者并发RM的独立危险因素。结论急性中毒患者发生RM与合并昏迷、抽搐、缺血缺氧存在密切的相关性。对合并上述危险因素的患者进行早期防治有重要意义。
objective To explore the risk factors of acute poisoning patients presenting with rhabdomyolysis （RM）. Methods Clinical data of 195 patients with acute poisoning were retrospectively analyzed.According to the incidence of RM or not,all patients were divided into the RM and non-RM groups. Clinical data were statistically compared between two groups. The variables with statistical significance （P〈0.05 ） were subject to multivariate logistic regression analysis. Results Among 195 patients with acute poisoning,44 patients developed RM with an incidence rate of 22.6%. Univariate analysis revealed that sex,age and serum lactic acid level did not significantly differ between two groups （all P〉0.05 ）. Drug category,serum sodium level,serum potassium level,APACHE Ⅱ score,whether complicated with coma,convulsion,infection,ischemia and anoxia or not significantly differed between two groups （all P〈0.05 ）. Multivariate regression analysis demonstrated that complicated with coma,convulsion,ischemia and anoxia were independent risk factors of acute poisoning complicated with RM. Conclusions The incidence of RM in patients diagnosed with acute poisoning is significantly correlated with coma,convulsion,ischemia and anoxia. Early prevention and treatment is of clinical significance for acute poisoning patients presenting with these complications.
出处
《新医学》
2016年第12期839-842,共4页
Journal of New Medicine
