摘要
目的:探讨加味双柏散配合三级阶梯止痛法对原发性肝癌疼痛患者的影响。方法:选取90例原发性肝癌患者为研究对象,随机分为对照组及治疗组,各45例。两组均予三级阶梯止痛法进行止痛治疗,治疗组再予加味双柏散外敷治疗。观察两组治疗前后疼痛评分、中医症状积分、生存质量的变化,评估其临床疗效。结果:总有效率对照组为82.2%,治疗组为95.6%,两组总有效率比较,差异有统计学意义(P<0.05)。对照组患者治疗期第7天用药后3 h疼痛评分高于同组治疗期第1天时对应时间点疼痛评分(P<0.05),治疗组患者治疗期第7天时用药前、用药后1 h、用药后3 h、用药后6 h疼痛评分均低于同组治疗期第1天时对应时间点疼痛评分(P<0.05);治疗期第7天时治疗组患者用药前、用药后1 h、用药后3 h、用药后6 h疼痛评分均低于同期对照组对应时间点(P<0.05)。治疗后两组患者胁痛、情志抑郁中医症状积分均低于同组治疗前(P<0.05),治疗后治疗组患者胁痛、情志抑郁中医症状积分均低于同期对照组(P<0.05)。治疗后两组心理功能、总分、自我评价评分均高于同组治疗前(P<0.05),而症状/副作用评分低于同组治疗前(P<0.05);治疗后治疗组心理功能、症状/副作用、总分、自我评价评分均高于同期对照组(P<0.05)。结论:加味双柏散联合三级阶梯止痛法可有效增强止痛药物止痛效果,降低止痛药副作用;改善患者情志,提高其生活质量。
Objective： To investigate the effect of modified Shuangbai powder combined with three-step method analgesic on primary hepatic cancer pain. Methods： The 90 cases of primary liver cancer patients were randomly divided into control and treatment groups, 45 cases in each. The patients were given three-step method analgesic for pain treatment in two groups, and patients in treatment group were treated with modified Shuangbai powder. The changes of pain score, TCM symptom score and quality of life were observed, and the efficacy was evaluated. Results： The total effective rate was 82.2% in the control group, and 95.6% in treatment group; there was significant difference between the two groups （P〈0.05）. At the 7th day, the control group showed higher pain score after medication 3 h than that of the 1st day at the corresponding time （P〈0.05）. At the 7th day, the treatment group showed lower pain scores before medication, after medication 3 h and after medication 6 h, than the same period at the 1st day （P〈0.05）; At the 7th day, the treatment group showed lower pain scores than control group before medication, after medication 1, after medication 3 h and after medication 6 h （P〈0.05）. After treatment, two groups showed lower chest pain, emotional depression and TCM symptom scores than before treatment （P〈0.05）; The treatment group showed lower chest pain, emotional depression symptom scores than the control group （P〈0.05）. The two groups showed higher mental function and total score, self eval- uation scores before treatment （P〈0.05）, while lower symptom/side effect score was than before treatment （P〈 0.05）; The tretment group showed higher psychological function, symptoms/side effects, total score, self evalua- tion scores than control group （P〈0.05）. Conclusion： The Shuangbai powder combined with three-step method analgesic can effectively enhance the analgesic effect, reduce side effects of analgesics and improve patients＇ emotion and quality of life.
出处
《中医药导报》
2016年第23期45-48,共4页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
关键词
加味双柏散
三级阶梯止痛法
原发性肝癌
疼痛
modified Shuangbai powder
three step analgesic method
primary liver cancer
pain
