摘要
目的探讨胰腺癌根治术后患者临床病理特征与预后的关系。方法回顾性分析行胰腺癌根治手术治疗的、病理确诊为胰腺导管腺癌的患者283例,分析其临床病理特征及生存情况。结果 283例患者的中位无瘤生存期(median disease free survival,m DFS)为7.9月,中位总生存期(median overall survival,m OS)为15.0月。多因素分析显示,肿瘤手术切缘状态以及肿瘤TNM分期是影响胰腺癌根治术后患者DFS的独立预后因素(均P<0.05),肿瘤淋巴结状态以及肿瘤TNM分期是影响胰腺癌根治术后患者OS的独立预后因素(均P<0.05)。结论对于胰腺癌根治术后患者,手术切缘状态和TNM分期是影响DFS的独立风险因素,TNM分期和肿瘤淋巴结状态是影响OS的独立风险因素。
Objective To investigate the relationship between the clinicopathological features and prognosis of pancreatic cancer patients after radical surgery. Methods All patients pathologically diagnosed as pancreatic ductal adenocarcinoma（ PDA） and receiving radical surgery were retrospectively analyzed. Their clinicopathological and survival data were examined. Results In two-hundred-and-eighty-three PDA patients with radical operation,the median disease-free survival（ m DFS） was 7. 9 months,and the median overall survial（ m OS） was 15. 0 months. Multi-variate analysis determined surgical margin and TNM stage as independent risk factors for DFS（ P〈 0. 05）. Lymph node status and TNM stage are independent risk factors for OS（ P〈 0. 05）. Conclusion For PDA patients treated with radical surgery,surgical margin and TNM stage are independent risk factors for DFS,while TNM stage and lymph node status are independent risk factors for OS.
作者
苏丹
白莉
Su Dan Bai Li(Oncology Department, Zhejiang Provincial People＇s Hospital, Hangzhou, 310014, China Oncology Department,PLA General Hospital, Beijing, 100853, China)
出处
《实用肿瘤杂志》
CAS
2016年第6期526-530,共5页
Journal of Practical Oncology
关键词
胰腺肿瘤
外科学
预后
pancreas neoplasm
surgery
prognosis
