摘要
目的:分析缬沙坦联合贝前列素钠对高血压合并早期肾损伤患者肾功能、凝血功能以及内皮损伤的影响。方法:200例高血压合并早期肾损伤患者按照治疗方法不同,分为观察组(接受缬沙坦联合贝前列素钠治疗)97例,对照组(接受单纯缬沙坦治疗)103例,对比两组治疗后肾功能、凝血功能以及内皮损伤指标水平差异。结果:治疗后8周时,观察组血浆中胱抑素C(CysC)、β2微球蛋白(β2-MG)、纤维蛋白原(Fib)、D-二聚体(D-D)、血小板平均容积(MPV)的含量以及尿液中尿蛋白肌酐比(UACR)、α1微球蛋白(α1-MG)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)的含量均显著低于对照组(P<0.05),血浆中抗凝血酶III(ATIII)含量高于对照组(P<0.05);观察组下肢动脉血流峰速(Vmax)显著高于对照组(P<0.05),颈动脉内膜中层厚度(IMT)以及下肢动脉阻力指数(RI)、血管内皮依赖性舒张功能(FMD)、血管扩张功能(NMD)均显著低于对照组(P<0.05)。结论:缬沙坦联合贝前列素钠可保护高血压合并早期肾损伤患者肾功能、避免病情进一步进展,是疾病治疗的理想方案。
Objective： To analyze the effect of valsartan combined with beraprost sodium on renal function, blood coagu- lation function and endothelial injury in patients with hypertension and early renal damage. Methods： A total of 200 patients with hypertension and early renal damage were divided into observation group （n = 97） （received valsartan combined with bera- prost sodium therapy） and control group （n = 103） （received valsartan therapy alone） according to different treatment methods. Differences in renal function, blood coagulation function and endothelial injury index levels were compared between the two groups after treatment, Results： A total of 8 weeks after treatment, cystatin C （CysC）, β2-microglobulin （β2-MG）, fibrinogen （Fib）, D-Dimer （D-D）, mean platelet volume （MPV） contents in plasma and urinary albumin ereatinine ratio （UACR）, α1- MG, n-acetyl-β-d-glucosaminidase （NAG） contents in urine of observation group were significantly lower than those of control group （P〈0.05） l antithrombin Ⅲ （ATⅢ） contents in plasma were significantly higher than that of control group （P〈0.05）lower limb artery Vmax value of observation group was significantly higher than those of control group （P〈0.05） ; carotid ar- tery intima-media thickness （IMT） value lower limb artery resistance index （RI）, flow-mediated dilatation （FMD） and nitro- glycerine-mediated dilatation （NMD） value were significantly lower than those of control group （P 〈0.05）. Conclusions： Val- sartan combined with beraprost sodium can protect the renal function and avoid further disease progression in patients with hy- pertension and early renal damage, and it is an ideal solution to disease treatment.
出处
《海南医学院学报》
CAS
2016年第24期2989-2992,共4页
Journal of Hainan Medical University
基金
延安大学资助项目(YD2008-45)~~
关键词
原发性高血压
肾损伤
缬沙坦
贝前列素钠
内皮功能
Primary hypertension
Renal damage
Valsartan
Beraprost sodium
Endothelial function
