摘要
目的:探讨2型糖尿病(T2DM)患者尿液肾损伤分子-1(KIM-1)及血清胱抑素C(CysC)水平与糖尿病肾损伤的相关性。方法:选择在邯郸市人民医院内科住院的T2DM患者130例,按24h尿白蛋白定量(24hUAE)水平分为3组:24hUAE<30mg组(正常蛋白尿组,55例);30mg<24h UAE<300mg组(微量蛋白尿组,40例);24hUAE>300mg组(大量蛋白尿组,35例)。另选50例同期健康体检者作为健康对照组。测定各组尿液KIM-1含量及血清CysC水平,并进行比较。结果:(1)与健康对照组比较,T2DM患者尿液KIM-1含量及血清CysC水平均明显升高(P均<0.01);(2)T2DM组内,与正常尿蛋白组比较,微量蛋白尿组和大量蛋白尿组尿液KIM-1含量[(1.0±0.3)pg/mg比(1.6±0.6)pg/mg比(3.0±1.2)pg/mg]及血清CysC[(1.05±0.25)mg/L比(3.11±0.22)mg/L比(5.96±0.37)mg/L]水平明显升高,且大量蛋白尿组升高更显著(P<0.05或<0.01);(3)直线相关分析显示,糖尿病患者尿液KIM-1含量及血清CysC水平呈显著正相关(r=0.809,P=0.021)。结论:尿液肾损伤分子-1含量及血清胱抑素C水平是可以反映糖尿病早期肾损伤的实验室指标,对糖尿病的肾损害早期诊断及疗效判断具有较好的临床价值。
Objective：To explore correlation among levels of urinary kidney injury molecule（KIM）-1,serum cystatin C（CysC）and diabetic renal injury in patients with type 2 diabetes mellitus（T2DM）.Methods：A total of 130T2 DM patients hospitalized in department of internal medicine of our hospital were selected.According to 24 hurinary albumin excretion（UAE）,they were divided into 24hUAE30mg group（normal proteinuria group,n=55）,30mg24hUAE 300 mg group（microalbuminuria group,MAU group,n=40）and 24 h UAE300 mg group（massive albuminuria group,n=35）.Another 50 healthy subjects undergoing physical examination simultaneously were regarded as healthy control group.Urinary KIM-1 and serum CysC concentration were measured and compared among all groups.Results：（1）Compared with healthy control group,there were significant rise in urinary KIM-1 concentration and serum CysC level in T2 DM patients,P〈0.01all;（2）In T2 DM group,compared with normal proteinuria group,there were significant rise in urinary KIM-1 concentration[（1.0±0.3）pg/mg vs.（1.6±0.6）pg/mg vs.（3.0±1.2）pg/mg]and serum CysC level[（1.05±0.25）mg/L vs.（3.11±0.22）mg/L vs.（5.96±0.37）mg/L]in MAU group and massive albuminuria group,and they were significantly higher in massive albuminuria group,P〈0.05or0.01;（3）Linear correlation analysis indicated that urinary KIM-1 concentration was significant positively correlated with serum CysC level（r= 0.809,P=0.021）in DM patients.Conclusion：Urinary KIM-1 concentration and serum CysC level are laboratory indexes reflecting early renal injury in DM,which possess good application value for early diagnosis and therapeutic effect judgment of renal injury in DM.
作者
张寒
闫红
王艳红
乔玲
ZHANG Han YAN Hong WANG Yan-hong QIAO Ling(Department of Internal Medicine, People＇s Hospi- tal of Handan City, Handan, Hebei, 056001, China)
出处
《心血管康复医学杂志》
CAS
2016年第5期498-500,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
