摘要
目的研究藏药色吉美多Herpetospermum caudigerum Wall种子的化学成分。方法通过多种柱层析和重结晶的方法分离纯化色吉美多乙酸乙酯部位,利用理化性质,TLC和核磁共振氢谱等分析测试手段鉴定化合物结构。结果从色吉美多乙酸乙酯部位分离并鉴定了5个化合物,分别为波棱素(I),葫芦素R(II),波棱醛(III),去氢双松伯醇(IV),齐墩果酸(V)。结论化合物II、V为首次从该植物中分离得到。
Objective To investigate the chemical constituents of the seed of Herpetospermum caudigerum Wall. Methods The chemical constituents were isolated by using a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, and recrystallization. Their structures were elucidated by physical and chemical properties, and spectrum analysis （TLC, 1H-NMR and so on）. Results Five compounds were identified as Herpetin （I）, Cucurbitacin R（II）, Herpetal（III）, Dehydrodiconiferyl alcohol（IV）, and Oleanic acid（V）. Conclusion Compounds II and V were obtained from this plant for the first time.
出处
《现代中药研究与实践》
CAS
2016年第5期30-32,共3页
Research and Practice on Chinese Medicines
基金
南京大学医药生物技术国家重点实验室开放基金(01KF-201404)
国家自然科学基金(81274168
81573563)
国家重大专项"重大新药创制"(2012ZX09304005-002)
关键词
色吉美多
乙酸乙酯部位
化学成分
分离纯化
Herpetospermum caudigerum Wall
ethyl acetate fraction
chemical compositions
separationand purification
