摘要
目的探讨中性粒细胞/淋巴细胞比值（NLR）与ST段抬高的心肌梗塞（STEMI）患者经皮穿刺冠脉介入治疗（PCI）后心室重构（VR）的关系。方法连续回顾327例STEMI行PCI的患者,入院和24 h后采集血液标本并检测WBC、中性粒细胞（N）、淋巴细胞（L）、血红蛋白（Hb）和其他包括CK-MB质量的生化指标。入院和心梗后6个月检测心电图。按有无VR将患者分为2组：VR组（87例）和非VR组（240例）。结果与非VR组比较,VR组患者NLR、峰值CK-MB显著较高,差异有统计学意义（P〈0.05）。多因素回归分析发现,NLR升高为STEMI患者PCI术后发生VR的独立风险因素（OR=1.836,95%CI：1.425~4.239,P〈0.01）。结论 NLR是STEMI患者PCI术后发生心室重构等不良心血管事件有用的预测指标,临床应加强对基础NLR升高患者的管理。
Objective To explore the relationship between neutrophil to lymphocyte ratio（ NLR） and ventricular remodeling（ VR）in patients with ST- elevation myocardial infarction（ STEMI） after percutaneous coronary intervention（ PCI）. Methods 327 consecutive patients with STEMI who underwent PCI were included in this study. Blood samples at admission and 24 hours later were collected for measuring WBC,neutrophils（ N）,lymphocytes（ L）,hemoglobin（ Hb） and other biochemical markers included CK- MB. Echocardiography（ ECG） was performed during admission and at six months after myocardial infarction. Patients were divided into 2 groups with their VR status： VR（ 87 cases） and non- VR（ 240 cases）. Results Compared with the non-VR group,NLR and peak CK- MB were significantly higher in patients with VR,with the differences statistically significant（ P〈0. 05）. Multivariate Logistic regression analysis showed that NLR increase was independent risk factor of VR in STEMI patients after PCI（ OR = 1. 836,95% CI： 1. 425- 4. 239,P〈0. 01）. Conclusion NLR is useful for predicting adverse cardiovascular events such as ventricular remodeling in STEMI patients after PCI,which suggests patients with higher initial NLR should be given more medical care.
出处
《中国卫生检验杂志》
CAS
2016年第21期3137-3140,共4页
Chinese Journal of Health Laboratory Technology
