摘要
目的了解药品不良反应（adverse drug reactions,ADR）报告中超说明书用药的情况,为临床合理用药提供参考。方法对2014年1-12月收集的药品不良反应报告共700例进行回顾性分析,根据药品说明书对超说明书用药情况进行分析。结果 700例ADR报告中,共有医嘱1 605条,有267份超说明书用药报告（38.1%）,有416条超说明书医嘱（25.9%）,类型主要为超给药频次、超给药剂量和超适应症,超说明书用药构成比居前3位的药物依次为银杏达莫注射液、前列地尔注射液和注射用美洛西林钠。结论 ADR报告中超说明书用药情况普遍存在,需加强监管,促进临床合理用药,减少ADR的发生。
OBJECTIVE To investigate the situation of off-label drug uses of drug adverse reaction reports, and to promote clinical rational drug use. METHODS A retrospective analysis was conducted on 700 cases of adverse drug reactions reported in our hospital in 2014, according to the drug instructions. RESULTS A total of 1 605 drug prescriptions was recorded in 700 cases of ADR reports, 267 ADR reports involved off-label drug uses（38.1%）, 416 drug prescriptions involved off-label drug uses（25.9%）. The top three types of off-label uses were off-label administration frequency, overdose, and off-indication use; and the top three drugs were Ginkgo Dipyidamolum, Alprostadil injection, and mezlocillin sodium for injection. CONCLUSION Off-label drug uses are common in ADR reports in our hospital. It is important to tighten monitoring on the off-label drug uses and to promote clinical rational drug uses so as to reduce the incidence of ADR.
作者
任燕萍
芦小燕
周菲
龚燕波
张灵灵
REN Yanping LU Xiaoyan ZHOU Fei GONG Yanbo ZHANG Lingling(Ningbo No.2 Hospital, Ningbo 315010, China)
出处
《中国现代应用药学》
CAS
CSCD
2016年第11期1474-1477,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
药品不良反应
超说明书用药
adverse drug reactions
off-label drug uses
