摘要
目的观察银杏达莫注射液对老年慢性肾功能不全患者造影剂肾病(CIN)的影响。方法接受冠状动脉造影的老年慢性肾功能不全患者63例,随机分为观察组(32例)及对照组(31例)。两组均在造影前常规水化治疗。观察组在水化基础上,术前6h予银杏达莫注射液25ml加入生理盐水250ml静脉滴注,术后第1和第2天重复使用1次。观察两组造影前后血清肌酐(SCr)及肌酐清除率(Ccr)水平,比较CIN发病率。结果两组术后48hSCr均较术前升高,Ccr较术前降低(P<0.05)。术后48h,观察组SCr低于对照组[(191.0±22.3)μmol/L vs.(199.5±26.6)μmol/L](P<0.05),观察组Ccr高于对照组[(36.1±4.2)ml/min vs.(33.4±6.3)ml/min](P<0.05);观察组术后CIN发病率低于对照组(9.4%vs.12.9%)(P<0.05)。结论银杏达莫注射液对肾功能有保护作用,能减少老年慢性肾功能不全患者冠状动脉介入治疗术后CIN的发病率。
Objective To investigate the effect of Ginkgo leaf extract and dipyridamole injection （GDI） on the contrast-induced nephropathy（CIN） in senile patients with chronic renal insufficiency undergoing coronary artery interventional therapy（CAIT）. Methods A total of 63 patients undergoing CAIT was assigned into two groups of A（32 cases） and B（31 cases）, who were with chronic renal insufficiency and were prepared with conventional hydration treatment before CAIT. GDI 25 ml in normal saline 250 ml was infused at 6 hours before CAIT in group A,which was repeated on the 1st and 2nd day after CAIT. Serum creatinine（SCr） and creatinine clearance rate （Ccr） were detected before and after CAIT. The incidence of CIN was compared between two groups. Results Compared to before,SCr level was increased and Ccr was decreased after CAIT in both groups. At 48 hours after CAIT,SCr level was lower and Ccr was higher in group A than those in group B[（191.0±22.3） μmol/L vs. （199.5±26.6） μmol/L and （36.1±4.2） ml/min vs. （33.4±6.3） ml/min] （P〈0. 05）. The incidence of CIN was lower in group A than that in group B（9.4% vs. 12.9%） （P〈0. 05）. Conclusion GDI has a protective effect on renal function and could reduce the incidence of CIN in the elderly with chronic renal insufficiency undergoing CAIT.
出处
《江苏医药》
CAS
2016年第21期2327-2329,共3页
Jiangsu Medical Journal
关键词
银杏达莫注射液
肾功能不全
造影剂肾病
Ginkgo leaf extract and dipyridamole injection
Renal dysfunction
Contrast-induced nephropathy
