摘要
目的:分析血液透析联合血液灌流的作用,并探讨对维持性透析患者钙磷代谢紊乱的疗效。方法:以本单位2015年全年收治的进行维持性血液透析的患者100例为受试对象,随机分为实验组(50例)和对照组(50例),对照组仅接受血液透析治疗;实验组进行血液透析的基础上联合血液灌流治疗。比较两组患者透析前、透析后2、3、4个月尿素氮(BUN)、肌酐(Scr)、补体C3、β2微球蛋白(β2-MG)、血磷(P)、钙磷乘积、血清全段甲状旁腺激素(i PTH)、维生素D3(1,25(OH)D3)的水平,比较两组患者血清白蛋白(Alb)、胆固醇(TC)、血红蛋白(Hb)、红细胞水平(RBC),并分析其临床意义。结果:两组患者透析后各时间段BUN、Scr水平均较透析前显著降低,补体C3水平则在透析4个月后显著升高;而两组患者透析后各时间段肾功能评价指标无显著差异;实验组各时间段钙磷代谢指标较透析前和对照组显著改善;实验组透析后3、4个月营养状况较透析前、对照组均有所改善,对照组营养状况无显著差异。结论:血液透析联合血液灌流有助于维持性血液透析患者体内毒素的清除,纠正钙磷代谢紊乱,改善患者营养状况,值得推广使用。
Objective：To analyze the importance of hemodialysis combined with hemoperfusion, and discuss the effcacy on the treatment of phosphorus and calcium metabolism disorder in the patients of maintenancing hemodialysis. Methods：All of the patients treated with maintenancing hemodialysis in our hospital during 2015 were selected. A summary of 100 patients with chronic renal failure were chosen and randomly classified into the control group （n=50） and the experimental group （n=50）. The control group were treated with hemodialysis, Whileexperimental group were treated with hemodialysis combined with hemoperfusion. The serum concentration of BUN, Scr, complement C3,β2-MG, P, Ca and P product, iPTH, 1,25（OH）-D3, Alb, TC, Hb, RBC between the two groups were compared. Results：BUN, Scr, complement C3,β2-MG in two groups were improved signiifcantly, while no statistical difference were found between the two groups;hTe indicators of phosphorus and calcium metabolism in experimental group at post-therapy became better than that in pre-therapy and in post-therapy of the control group. hTe indicators of nutritional status in experimental group at 3, 4 months atfer therapy were better than that of pre-therapy and the control group. hTere was no signiifcant difference in the nutritional status of the control group. Conclusion：The hemodialysis combined with hemoperfusion can help flush out toxins and correct the disorder of calcium and phosphorus metabolism and improve the nutritional status, it’s worthy of clinical promotion.
出处
《临床与病理杂志》
2016年第10期1579-1584,共6页
Journal of Clinical and Pathological Research
