摘要
目的观察隔姜艾灸足三里预防蒽环类药物所致心肌损害的效果,探索用祖国传统医学方法减轻化疗副反应的可行性。方法采用前瞻性自身交叉对照法,将病例随机分组,每组均化疗3个周期,3个周期中采用艾灸-右丙亚胺-艾灸+右丙亚胺三种方法循环使用,观察各组的心电图改变和心功能情况以及血清利钠肽(BNP)水平变化。结果三组病例的心电图改变率分别为33.33%、30.00%和、23.33%,差异无统计学意义(P>0.05);心功能情况比较差异无统计学意义(P>0.05);三组病例在每一期化疗后第1天BNP水平均较化疗前升高(P<0.05),但是组间比较差异无统计学意义(P>0.05)。结论艾灸与右丙亚胺预防心肌损害的机制不同,但效果相近,且艾灸操作简便、经济、副反应小,值得推广。
Objective To observe the effect of prevention of anthracycline-induced myocardial injury by ginger moxi- bustion on acupiont of Zusanli, and to explore the feasibility of relieving the the side effects of chemotherapy with the method of traditional chinese medicine（TCM）. Methods A prospective crossover control method was employed. The eases were randomly divided into three groups, each group had suffered 3 cycles of chemotherapy, three ways of moxi- bustion-dexrazoxane-moxibustion＋dexrazoxane were employed to recycle in three cycles, electrocardiogram and heart function and blood natriuretic peptide（BNP） level were observed. Results The changes of electrocardiogram of three groups were 33.33%, 30.00%, and 23.33%, the difference was not statistically significant （P〉0.05）, heart function of three groups were compared with no significant differences （P〉0.05）, the BNP increased in each period of first day after chemotherapy were higher than those before chemotherapy （P〈0.05）, but there was no significant difference among groups（P〉0.05）. Conclusion Moxibustion with different mechanisms of prevention of myocardial damage compared to the dexrazoxane, the effect is similar, and the moxibustion has the advantages of simple operation, low cost, small side effect, worthy of promotion.
出处
《中国现代医生》
2016年第28期139-141,共3页
China Modern Doctor
基金
江西省卫生厅中医药科研基金(2007Z008)
关键词
血液病
恶性肿瘤
蒽环类药物
心肌损害
隔姜艾灸
足三里
BNP
Hematologic disease
Malignant tumor
Anthracycline
Myocardial damage
Ginger moxibustion
Zusanli
Blood natriuretic peptide
