摘要
目的 探讨标准化尘螨变应原免疫治疗方案用于变应性鼻炎的临床疗效及安全性。方法 选取2014年1月~2015年1月之间我院收治的188例变应性鼻炎患者作为研究对象,采用数字表法随机分为观察组和对照组各94例,对照组采用常规药物治疗,包括抗组胺药物、鼻用皮质类固醇等,观察组患者采用标准化尘螨变应原免疫治疗方案,两组患者均维持治疗1年,治疗结束后进行疗效评估及不良反应统计,并采用鼻结膜炎生活质量调查问卷（RQLQ）调查对比两组患者治疗前后的生活质量。结果 观察组患者总有效率为88.3%,显著高于对照组的54.3%,差异具有统计学意义（χ2=7.451,P〈0.05）;观察组患者共进行治疗期间共3例出现I级全身性反应,不良反应发生率为6.4%,但所有不良反应病例均经药物治疗后迅速缓解,对照组未发生明显全身性反应,两组对比无显著差异（χ2=1.947,P〉0.05）;治疗前两组患者的各项RQLQ评分对比均无显著差异,治疗后观察组患者的活动、睡眠、行为、鼻部症状、眼部症状、情感、总体生活质量评分均显著低于对照组,差异具有统计学意义（P〈0.05）。结论 标准免疫治疗方案用于变应性鼻炎患者的疗效确切,能够有效改善患者的临床症状,提高患者的生活质量,且安全性较好,值得在临床上推广和应用。
Objective To explore the clinical efficacy and safety of standardized dust mite allergen immunotherapy program in treatment of allergic rhinitis. Methods 188 cases of patients with allergic rhinitis cured in our hospital from January 2014 to January 2015 were selected as the study objects. According to digital table method, they were randomly divided into observation group and control group with 94 cases in each. Patients in control group were treated with routine medicine, including anti histamine drugs, nasal corticosteroids, etc. And patients in observation group were treated with standardized dust mite allergen immunotherapy program. The qualities of life of the two groups were compared before and after treatment by using the quality of life questionnaire （RQLQ）. Results The total effective rate of observation group was 88.3%, which was significantly higher than that of control group with 54.3%, and the difference was statistically significant （X2=7.451, P 〈 0.05）. A total of 3 I grade systemic reactions were occurred during the treatment period in observation group, the incidence of adverse reactions was 6.4%, but all the adverse reactions were relieved after drug treatment. In the control group, there was no significant systemic reaction. There was no significant difference between the two groups （X2=1.947, P〈 0.05）. There was no significant difference in RQLQ scores between the two groups before treatment. After treatment, activity, sleep, behaviors, nasal symptoms, eye symptoms, emotion, whole life quality score of observation group were significantly lower than those in the control group, with significant difference （P 〈 0.05）. Conclusion Standard immunotherapy in treatment of patients with allergic rhinitis has definite curative effect. It can effectively improve the patient＇ s clinical symptoms, and improve the quality of life of patients. The security is good. It is worth popularizing and applying in clinic.
出处
《中国医药科学》
2016年第16期215-217,221,共4页
China Medicine And Pharmacy
关键词
变应性鼻炎
抗原
免疫治疗
脱敏
生活质量
Allergic rhinitis
Antigen
Immunotherapy
Desensitization
Quality of life
