摘要
目的 观察不同术前免疫状态脊椎手术患者术后感染发生率及炎症介质水平的变化,为该类患者诊治措施的制定提供依据。方法 选取2014年2月-2016年1月医院收治96例脊椎手术患者为研究对象,将其根据CD3＋水平的不同分成3个组,A组32例患者CD3＋〉60%、B组32例患者CD3＋为50%-60%、C组32例患者CD3＋为〈50%,然后将3组患者术后感染发生率、术前及术后1d、3d炎症介质水平进行比较。结果 术后感染发生率C组患者为15.63%,其高于A组0及B组6.25%,B组的发生率则高于A组,术前及术后1d、3d炎症介质水平C组患者均高于A组及B组,B组则高于A组,差异均有统计学意义（P〈0.05）。结论 不同术前免疫状态脊椎手术患者术后感染发生率及炎症介质水平呈现明显的差异,应注意对上述指标的监测及改善。
OBJECTIVE To observe the changes of incidence of postoperative infection and levels of inflammatory mediators in spinal surgery patients with different preoperative immune state so as to provide guidance for clinical diagnosis and treatment of such group of patients .METHODS A total of 96 patients who underwent the spinal sur‐gery from Feb 2014 to Jan 2016 were recruited as the study objects and divided into three groups according to the level of CD3 ＋ ;32 patients with the CD3 ＋ more than 60% were assigned as the group A ,32 patients with the CD3 ＋ varying from 50% to 60% were set as the group B ,and 32 patients with the CD3 ＋ less than 50% were as‐signed as the group C .The incidence of postoperative infection and the levels of inflammatory mediators before the surgery and after the surgery for 1 and 3 days were observed and compared among the three groups of patients . RESULTS The incidence of postoperative infection of the group C was 15 .63% ,higher than 0% of the group A and 6 .25% of the group B;the incidence of postoperative infection of the group B was higher than that of the group A .The levels of inflammatory mediators were higher in the group C than in the group A and the group B before the surgery and after the surgery for 1 and 3 days;the levels of inflammatory mediators of the group B were higher than those of the group A ,and there was significant difference （P〈0 .05） .CONCLUSION The spinal sur‐gery patients with different preoperative immune state vary significantly in the incidence of postoperative infection and the levels of inflammatory mediators .It is necessary to pay attention to the monitoring and improvement of the above indexes .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第22期5172-5174,共3页
Chinese Journal of Nosocomiology
基金
河南省科技计划基金资助项目(152102310192)
关键词
术前免疫状态
脊椎手术
术后感染发生率
炎症介质水平
Preoperative immune state
Spinal surgery
Incidence of postoperative infection
Level of inflammato-ry mediator
