摘要
目的探讨多巴丝肼片联合盐酸司来吉兰治疗帕金森病(PD)患者的有效性和安全性。方法选取2014年5月至2015年5月梅州市中医医院收治的PD患者70例为研究对象,按随机数字表法分为观察组和对照组,每组35例。对照组患者采用多巴丝肼片治疗,观察组患者采用多巴丝肼片联合盐酸司来吉兰治疗,观察两组患者临床治疗效果。结果观察组患者治疗总有效率为80.0%,高于对照组的60.0%,差异有统计学意义(P<0.05);观察组患者的精神状态、运动功能、日常活动等帕金森统一评分量表评分均优于对照组,差异均有统计学意义(均P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用多巴丝肼片联合盐酸司来吉兰治疗PD疗效确切,可有效缓解患者的临床症状,减轻患者的不适,不良反应少,安全性高,可作为治疗PD的首选方法。
Objective To observe and analyze the effectiveness and safety of madopar combined with selegiline hydrochloride in the treatment of Parkinson＇s disease（PD）.Methods 70 patients with Parkinson＇s disease and who accepted treatments in our hospital from May,2014 to May,2015 were selected, and were divided into the observation group of 35 cases and the control group of 35 cases by the two color random grouping method. In the control group,they were treated with madopar while in the observation group, they were treated with the madopar combined with selegilinehydrochloride.Then,the clinical effect of two groups of patients were observed.Results The total effective rate in the observation group was 80%, which was higher than that in the control group of 60%（P〈0.05）;The mental state, motor function,daily activities and other UPDRS scores of patients in the observation group were better than those in the control group（P〈0.05）;There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）.Conclusion The clinical effects of madopar combined with selegiline hydrochloride in the treatment of Parkinson＇s disease are exactly, which can effectively relieve clinical symptoms, reduce patient＇s discomfort, and the adverse reactions is little, the safety is high,and it can be used as the treatment of choice for Parkinson＇s disease treatment method, thus it is worth to be applied in the clinical.
出处
《中国药物经济学》
2016年第10期35-37,共3页
China Journal of Pharmaceutical Economics
