摘要
目的观察第二代抗精神病药(SGAs)利培酮、奥氮平、喹硫平、齐拉西酮、阿立哌唑治疗首发精神分裂患者,研究QTc间期变化及其相关因素。方法收集北京回龙观医院2013年6月至2015年10月入院的首发精神分裂症患者共157例,比较QTc间期在用药前后的变化,及其影响因素的相关性,药物对QTc间期的影响。结果用药后2个月及3个月患者的QTc增加较基线期比显著延长(P<0.05)。5种不同SGAs与第2个月QTc间期变化没有相关性。所有可能的影响因素中只有所服抗精神病药物的剂量与QTc间期延长呈正相关(P=0.029)。结论使用第二代抗精神病药治疗发生QTc间期延长,并且是剂量相关的,与所服抗精神病药物种类无关,但得出这一结果可能受组间样本量差异太大的影响。
Objective To observe second generation antipsychotic drugs （SGAs） in the treatments of first episode schizophrenic patients and to study the changes of QTc intervals and its related factors. Methods 157 first-episode schizophrenia patients from Beijing Huilongguan Hospital during June 2013 to October 2015 were admitted in the study, and their QTc interval changes before and after drug treatments were recorded. The correlated factors and their influences on QTc intervals were analyzed. Results There were significant difference among the QTc intervals of patients before treatment（P〉 0.05）, after 2-months treatment and 3-months treatment. In regarding to QTc intervals in the second month, We found no difference among different SGAs（P 〉 0.05）. Among all the possible factors, We only found correlation between the doses of antipsychotic drugs and the prolongation of the QTc intervals （P = 0.029） . Conclusions The use of the second generation antipsychotic drugs may lead to prolongation of QTc intervals. The prolongation is dose-related, but not related to the types of antipsychotic drugs, but this result may be affected by the difference in sample size between groups.
出处
《国际精神病学杂志》
2016年第5期788-790,793,共4页
Journal Of International Psychiatry
基金
北京市属医院科研培育计划项目(PX2016067)
