摘要
红斑狼疮（lupus erythematosus,LE）是一种典型的自身免疫性疾病。其发病机制复杂,至今尚不完全清楚,核心为免疫耐受缺陷和干扰素-α（IFN-α）信号通路的上调。该病为一病谱性疾病,大约70%-85%的患者有皮肤受累。疾病一端为皮肤型红斑狼疮（Cutaneous lupus erythematosus,CLE）,病变主要限于皮肤;另一端为系统性红斑狼疮（systemic lupus erythematosus,SLE）,病变可累及多系统和多脏器。在SLE患者,皮肤损害常为首发表现,正确认识这些皮损,进行早期诊断和治疗,有利于预防重要靶器官的损害,从而改善疾病预后。
Lupus erythematosus（LE） is a typical autoimmune disease which remain keeping unclear pathogenesis. But the key pathogenesis is immune tolerance defect and up regulation of interferon alpha （IFN-） signaling pathway. LE is a series of spectrum diseases about 70% - 85% patients＇ skin were involved. A termination of LE is cutaneous lupus erythematosus（CLE） , which mainly involves the skin. One the other termination of LE is systemic lupus erythematosus（SLE） , which involves multiple system and organs. Most of SLE patients suffered from skin lesion as the first manifestation. To distinguish these lesions and deal with them properly is crucial for preventing viscera injury and improve prognosis.
出处
《皮肤病与性病》
2016年第5期331-336,共6页
Dermatology and Venereology
关键词
皮肤型红斑狼疮
诊断
治疗
Cutaneous lupus erythematosus
Diagnosis
Treatment
