摘要
目的探究0.5%马来酸噻吗洛尔滴眼液外用治疗中度风险婴幼儿血管瘤的临床疗效、安全性及必要性。方法将入选的82例中度风险血管瘤患儿随机分成两组,治疗组52例给予0.5%马来酸噻吗洛尔滴眼液局部外敷,对照组30例给予生理盐水外用。每日早晚各使用1次,每月门诊复查,持续监测至患儿满1岁龄,最后用Achauer疗效评定法判定临床疗效。结果治疗组:Ⅳ级(优)8例,Ⅲ级(好)27例,Ⅱ级(中)11例,Ⅰ级(差)6例,总有效率为88.46%。对照组:Ⅳ级(优)2例,Ⅲ级(好)3例,Ⅱ级(中)7例,Ⅰ级(差)18例,总有效率40.00%。两组有效率差异具有明显统计学意义(P<0.05)。82例患儿治疗过程中均未见明显不良反应。结论对于中度风险婴幼儿血管瘤应早期给予适当干预;0.5%马来酸噻吗洛尔滴眼液外用治疗疗效确切,不良反应少,患儿耐受性好。
Objective To study the clinical efficacy,safety and necessity of topical timolol maleate ophthalmic solution on medium risk infantile hemangi- omas. Method A total of 82 cases of infantile hemangioma were randomly divided into two groups. The treatment group with 52 cases had been treated with topical timolol maleate ophthalmic solution, while the control group with 30 cases had been treated with physiological saline. The treatment conducted was twice a day, once in the morning and once at night. Continuous monitoring to the child is one year old. Each month reexamines 1 time. In the end, the clinical efficacy was determined by the Achauer curative effect evaluation method. Results In the treatment group, respectively as 8 cases of grade Ⅳ, 27 cases of grade Ⅲ, 11 cases of grade Ⅱ , 6 cases of grade I and the total effective rate was 88.46%. In control group, respectively as 2 cases of grade Ⅳ, 3 cases of grade Ⅲ, 7 cases of grade Ⅱ , 18 cases of grade Ⅰ and the total effective rate was 40.00%. The difference between the two groups has statistical significant （ P〈 0.05 ） . All of 82 cases of patients had no significant adverse reactions. Conclusion For medium risk IH should still give appropriate intervention as early as possible. The timolol maleate ophthalmic solution has a significant curative effect to medium risk IH. There was no obvious adverse reactions during the treatment course. Children had good tolerance.
出处
《皮肤病与性病》
2016年第5期319-321,共3页
Dermatology and Venereology
基金
昆明市卫计委"十百千"儿童血管瘤诊疗技术中心编号:SW(技)-65
关键词
噻吗洛尔
婴幼儿血管瘤
临床疗效
Timolol maleate
Infantile hemangiomas
Clinical efficacy
