摘要
目的分析老年乙肝(CHB)和乙肝病毒(HBV)相关肝硬化患者外周血辅助性T细胞17(Th17)临床意义,探讨Th17对相关疾病的诊断价值。方法将我院收治的老年HBV感染者按病变类型分为CHB组及HBV相关性肝硬化组,另选80例老年健康体检者纳入正常组。比较各组Th17频率、白细胞介素-17(IL-17)、α-平滑肌肌动蛋白(α-SMA)表达与分布,探讨Th17、IL-17、α-SMA表达的相关性。结果 HBV相关肝硬化组Th17频率、IL-17、IL-17 m RNA及α-SMA水平显著高于CHB组,CHB组上述指标显著高于正常组(P<0.05)。CHB组ALT、HBV DNA载量显著高于HBV相关性肝硬化组,而TBIL显著低于后者,两组ALT、TBIL均显著高于正常组(P<0.05)。相关性分析表明,Th17频率与IL-17、α-SMA呈正相关(P<0.05),与ALT、TBIL、HBV DNA载量无明显相关性(P>0.05)。结论老年肝病患者Th17频率与肝脏炎症程度变化密切关联,检测Th17频率有助于早期明确疾病严重程度,预测病情转归。
Objective To analyze the effect of Th17 of patients with CHB and HBV related cirrhosis, and investigate the value of Th17 for related diseases. Methods Elderly patients with HBV infection were divided into CHB group and HBV related cirrhosis group. 80 healthy persons were selected as normal group. The Th17 frequency, IL-17, α-SMA of each group were compared and their correlation was investigated. Results The Th17 frequency, IL-17, IL-17 mRNA, α-SMA in HBV related cirrhosis group were higher than CHB group, also higher than normal group （P〈0.05）. The ALT, HBV DNA loads in CHB group were higher, the TBIL was lower than HBV related cirrhosis group, while the ALT and TBIL in the former two groups were higher than normal group（P〈O.05）. Correlation analysis showed that Th17 frequency was positively correlated with IL-17 and α-SMA（P〈0.05）, it was not correlated with ALT, TBIL, HBV DNA loads（P〉 0.05）. Conclusion The Th17 frequency of elderly patients with liver disease increase gradually and is closely correlated with the changes of liver inflammation, detection of the Th17 frequency can help to identify the disease severity and predict the prognosis.
出处
《中国现代医生》
2016年第26期37-39,共3页
China Modern Doctor
