不稳定型心绞痛患者血清内脏脂肪素水平的变化及与血管内皮细胞黏附分子的相关性被引量：13

Study on the Change of Serum Visfatin Level in Patients with Unstable Angina and Its Correlation with Vascular Endothelial Cell Adhesion Molecules

暂未订购

导出

摘要目的观测不稳定型心绞痛(UA)患者血清内脏脂肪素(visfatin)水平的变化,并探讨血清Visfatin与可溶性血管细胞黏附分子1(s VCAM-1)、可溶性细胞间黏附分子1(s ICAM-1)之间的相关性。方法采用定量夹心酶联免疫检测技术对80例UA患者(UA组)、68例稳定型心绞痛(SA)患者(SA组)及60例健康对照者(对照组)血清Visfatin、s VCAM-1、s ICAM-1水平的变化进行检测,同时常规检测其他临床生物化学指标。在UA组,采用Pearson相关检验对血清Visfatin与s VCAM-1、s ICAM-1、高敏C反应蛋白(hs-CRP)及其他生物化学指标进行相关性分析。结果 UA组血清Visfatin、s VCAM-1、s ICAM-1水平显著高于SA组及对照组(P<0.05、P<0.01)。UA组血清Visfatin水平与s VCAM-1(r=0.332,P<0.01)、s ICAM-1(r=0.479,P<0.01)、hs-CRP(r=0.521,P<0.01)水平呈显著正相关,而与腰围、体质指数、血压及其他生物化学指标无明显相关性。SA组、对照组血清Visfatin、s VCAM-1、s ICAM-1水平没有显著性差异(P>0.05)。结论 UA患者血清Visfatin水平显著升高,并与s VCAM-1、s ICAM-1、hs-CRP呈正相关,提示血清Visfatin与血管内皮损伤及斑块的不稳定性密切相关,可能为血管内皮损伤的标志物。 Aim To observe the change of serum Visfatin level in patients with unstable angina（ UA）; To investigate the correlation between serum Visfatin and soluble vascular cell adhesion molecule-1（ s VCAM-1）,soluble intercellular cell adhesion molecule-1（ s ICAM-1）. Methods The changes of serum Visfatin,s VCAM-1 and s ICAM-1 levels were detected by using quantitative sandwich enzyme-linked immunosorbent assay in 80 UA patients（ UA group）,68 patients with stable angina（ SA group） and and 60 healthy subjects（ control group）. Other clinical biochemical indexes were routinely detected at the same time. In the UA group,the relationships between serum Visfatin and s VCAM-1,s ICAM-1,high-sensitivity C-reactive protein（ hs-CRP）,other biochemical indexes were analysed by Pearson correlation test. Results The levels of serum Visfatin,s VCAM-1 and s ICAM-1 in UA group were significantly higher than those in SA group and control group（ P〈0. 05,P〈0. 01）. In the UA group,serum Visfatin level was significantly positively correlated with s VCAM-1（ r = 0. 332,P〈0. 01）,s ICAM-1（ r = 0. 479,P〈0. 01）,hs-CRP（ r = 0. 521,P〈0. 01）,but there was no significant correlation between serum Visfatin and waist circumference,body mass index,blood pressure,other biochemical indexes. There were no significant differences in serum Visfatin,s VCAM-1 and s ICAM-1 levels between the SA group and the control group（ P〉0. 05）. Conclusions The level of serum Visfatin is significantly increased,and is positively correlated with s VCAM-1,s ICAM-1 and hs-CRP in UA patients. It is suggested that serum Visfatin is closely related to vascular endothelial injury and plaque instability,so it may be a marker of vascular endothelial injury.

作者刘海宁孙金玲夏尉珉 LIU Hai-Ning SUN Jin-Ling XIA Wei-Min(Department of Cardiology, Zibo Central Hospital Affiliated to Binzhou Medical College, Zibo, Shandong 255036, Chin)

机构地区滨州医学院附属淄博市中心医院心内科

出处《中国动脉硬化杂志》 CAS 北大核心 2016年第10期1027-1030,共4页 Chinese Journal of Arteriosclerosis

关键词不稳定型心绞痛内脏脂肪素黏附分子血管内皮 Unstable Angina Visfatin Adhesion Molecule Vascular Endothelium

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献11

1Wang ZX, Nakayama T. Inflammation, a link between obesity and cardiovascular disease [J]. Mediators Inflamm, 2010, 2010 ( 1 ) : 535 918.
2Dahl TB, Yndestal A, Skjelland M, et al. Increased expression of visfatin in macrophages of human unstable carotid and coronary ath- erosclerosis: possible role in inflammation and plaque destabilization [J]. Circulation, 2007, 115(8): 972-980.
3Ling S, Nheu L, Komesaroff PA. Cell adhesion molecules as phar- maceutical target in atheroselerosis [J]. Mini Rev Med Chem, 2012, 12(2) : 175-183.
4Stastny J, Bienertova-Vasku J, Vaska A. Visfatin and its role in o- besity development [J]. Diabetes Metab Syndr, 2012, 6 (2) : 120-124.
5Kocelak P, Olszanecka-Glinianowicz M, Owezarek A J, et al. Plasma visfatin/nicotinamide phosphoribosyhransferase (visfatin/ NAMPT) concentration in elderly subjects with metabolic syndrome [J]. Pol Arch Med Wewn, 2015, 125(6) : 402-413.
6Adya R, Tan BK, Punn A, et al. Visfatin induces human endothelial VEGF and MMP-2/9 production via MARK and PI3K/ Akt signaling pathways: novel insights into visfatin-induced angio- genesis[J]. Cardiovasc Res, 2008, 78(2) : 356-365.
7Hulok A, Sciborski K, Marczak J, et al. Soluble cell adhesion mole- cules--Does estimating sVCAM-1 and sICAM-1 concentration provide additional information about cardiovascular risk in patients with coro- nary artery disease? [J]. Adv Clin Exp Med, 2014, 23 (5) : 735-741.
8Lee WJ, Wu CS, Lin H, et al. Visfatin-induced expression of in- flammatory mediators in human endothelial cells through the NF- kappa B pathway[J]. Int J Obes (Lond), 2009, 33(4) : 465-472.
9Axclssou J, Witasp A, Carrero JJ, et al. Circulating levels of visfa- tin/pre-B-cell colony-enhancing factor 1 in relation to genotype, GFR, body composition, and survival in patients with CKD[J]. Am J Kidney Dis, 2007, 49(2) : 237-244.
10Lu YC, Hsu CC, Yu TH, et al. Association between visfatin levels and coronary artery disease in patients with chronic kidney disease [J]. Iran J Kidney Dis, 2013, 7(6) : 446-452.