摘要
目的如何更加准确、敏感地反映移植肾的功能是临床关注的焦点,文中旨在探讨^(99)Tc^m-DTPA肾动脉显像测定肾小球滤过率(glomerular filtration rate,GFR)评估肾移植术后移植肾功能的临床价值。方法回顾性分析2015年8月至2016年1月南京军区南京总医院74例肾移植术后患者的^(99)Tc^m-DTPA肾动态显像法所测GFR值,根据血清肌酐值的范围分2组:正常组(17例)、异常组(57例),分析2组间移植肾GFR值,并分析GFR值与血清肌酐的相关性,55例患者行移植肾穿刺活检术,分析其病理结果并比较GFR值。结果正常组的平均GFR值较异常组升高[(61.7±15.6)vs(37.7±15.4)m L/min,P<0.001]。74例核素测量移植肾平均GFR值(43.2±18.4)m L/min,平均血清肌酐值(1.84±0.82)mg/d L,两者呈负相关(r=-0.673,P<0.001)。病理正常者平均GFR值高于异常者[(59.2±8.5)vs(39.6±16.5)m L/min,P=0.040]。结论^(99)Tc^m-DTPA肾动态显像能敏感的反应移植肾功能的变化,是监测移植肾功能变化的无创性检查方法之一。
Objective How to examine the function of transplanted kidney more accurately and sensitively has become a focus of clinical attention.This study was to investigate the value of ^99 Tc^m-DTPA renal dynamic imaging in evaluating the function of transplanted kidney by glomerular filtration（ GFR） after transplantation. Methods Patients were collected from August 2015 to January 2016 in Nanjing General Hospital of Nanjing Military Region. GFR was measured in 74 cases of kidney transplantation patients using the ^99 Tc^m-DTPA renal dynamic imaging.According to the range of serum creatinine,we divided the 74 cases into two groups：the normal group（ n=17） and abnormal group（ n=57） . We analysed the GFR between two groups and the correlation of GFR and serum creatinine .Transplanted kidney puncture biopsy was operated in 55 patients. We analysed the pathological results and compared the GFR. Results Compared with the abnormal group （GFR=37.7±15.4 mL/min）,the average GFR was higher in the normal group（GFR =61.7±15.6 mL/min）（P〈0.001）. The average GFR（43.2±18.4 mL/min） measured by ^99 Tc^m-DTPA renal dynamic imaging in 74 cases was positive correlated with average serum creatinine（1.84±0.82 mg/dL）（r=-0.673, P〈0.001）.Compared with patients with abnormal pathological results（GFR=39.6±16.5mL/min）, normal people had higher average GFR （ GFR=59. 2 ± 8. 5 mL/min ） （ P=0. 040 ） . Conclusion ^99 Tc^m-DTPA renal dynamic imaging can reflect the function of transplanted kidney sensitively, it is one of the noninvasive＆amp;nbsp;examination to monitor the function in transplanted kidney.
出处
《医学研究生学报》
CAS
北大核心
2016年第10期1055-1058,共4页
Journal of Medical Postgraduates
基金
国家自然科学基金(81401468)
关键词
肾小球滤过率
血清肌酐
放射性核素
肾移植
Glomerular filtration rate
Serum creatinine
Radioactive nuclide
Kidney transplantation
